DMD -- McGinnity et al. 28 (11): 1327 Table 1

TABLE 1
CYP isoform characterization of individual HLM pools

Isoform Probe Batch 1 Batch 2 Batch 3

pmol/min/mg

P450 content CO difference spectrum 320^a 280^a 430^a

P450 reductase Cytochrome c reduction 69000 84000 75000

CYP 7-Ethoxycoumarin O-demethylation 255 210 240

CYP1A2 Phenacetin O-dethylation 366 310 193

CYP2A6 Coumarin 7-hydroxylation 17200 81900 58600

CYP2E1 Chlorzoxazone 6-hydroxyline 1010 1911 1441

CYP2C Mephenytoin 4-hydroxylation 27 233 11

CYP2D6 Dextromethorphan O-demethylation 200 84 106

CYP3A Testosterone 6 $beta$ -hydroxylation 2600 1500 1900

CYP4A Lauric acid 11-hydroxylation 1000 1600 1600

^a Picomoles of CYP per milligram of microsomal protein.