|
|
TABLE 3
CLint of marker substrates in different HLM pools and
literature values
|
|
| Compound |
CLint
|
References |
| Batch
1 |
Batch 2 |
Batch 3 |
Mean |
Literature |
|
|
µl · min 1mg1 |
| Tolbutamide |
|
|
|
0.7a |
0.5-2.5;
1 ± 0.2 |
Iwatsubo et al. (1997),
Doecke et al. (1991), Back et al. (1988), Bourrie et al. (1996), Obach
(1999) |
| Diazepam |
3
± 1 |
2 |
2 |
3
± 1 |
2.6 ± 0.8 |
Obach (1999) |
| Metoprolol |
7 ± 1 |
5 |
5 |
6
± 1 |
14, 19 |
Mautz et al. (1995) |
| Ibuprofen |
14 |
5 |
5 |
8
± 2 |
9.6 ± 1.1 |
Obach (1999) |
| Propranolol |
16
± 3 |
16 |
15 |
15 ± 0 |
11-60 |
Lave
et al. (1997), Obach (1997), Otton et al. (1990) |
| Dextromethorphan |
29 ± 3 |
30 |
33 |
29
± 3 |
25-103 |
Kerry et al. (1994), Broly
et al. (1990) |
| Omeprazole |
43 ± 7 |
11 |
15 |
34
± 14 |
18, 26 |
Andersson et al. (1993),
Kobayashi et al. (1994) |
| Diltiazem |
56 ± 7 |
22 |
22 |
45
± 16 |
17 ± 2 |
Obach (1999) |
| Testosterone |
81
± 12 |
23 |
35 |
60 ± 18 |
| Verapamil |
380
± 44 |
111 |
114 |
256 ± 100 |
139 ± 3 |
Obach
(1999) |
|
|
a
Determined from
Vmax/Km. Where determined,
results are presented as mean ± S.D.
|
|