TABLE 6
Determination of CYP Cl
int
for marker and AR-C compounds
Compound
CL
int
HLM
CYP
µl · min
1
mg
1
Tolbutamide
0.7
a
1.3
a
Diazepam
3 ± 1
2 ± 1
Metoprolol
6 ± 1
7 ± 0
Ibuprofen
8 ± 2
20 ± 5
Propranolol
15 ± 0
55 ± 15
Dextromethorphan
29 ± 3
14 ± 1
Omeprazole
34 ± 14
131 ± 25
Diltiazem
45 ± 16
60 ± 3
Testosterone
60 ± 18
40 ± 3
Verapamil
256 ± 100
114 ± 11
a
Determined from
V
max
/
K
m
. Mean ± S.D.
1mg