DMD Large equally mixed donor pool

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Madyastha, K. M.
Right arrow Articles by Gaikwad, N. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Madyastha, K. M.
Right arrow Articles by Gaikwad, N. W.

Vol. 27, Issue 1, 74-80, January 1999

Metabolic Disposition of a Monoterpene Ketone, Piperitenone, in Rats: Evidence for the Formation of a Known Toxin, p-cresol

K. Madhava Madyastha and Nilesh W. Gaikwad

Bio-organic Section, Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012 (K.M.M., N.W.G.), Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India (K.M.M.)

It was shown earlier that the monoterpene ketone, piperitenone (I) is one of the major metabolites of R-(+)-pulegone, a potent hepatotoxin. In the present studies, the metabolic disposition of piperitenone (I) was examined in rats. Piperitenone (I) was administered orally (400 mg/kg of the b. wt./day) to rats for 5 days. The following urinary metabolites were isolated and identified by various spectral analyses: p-cresol (VI), 6,7-dehydromenthofuran (III), p-mentha-1,3,5,8-tetraen-3-ol (IX), p-mentha-1, 3,5-triene-3, 8-diol (X), 5-hydroxypiperitenone (VIII), 7-hydroxypiperitenone (XI), 10-hydroxypiperitenone (XII), and 4-hydroxypiperitenone (VII). Incubation of piperitenone (I) with phenobarbital-induced rat liver microsomes in the presence of NADPH resulted in the formation of five metabolites which have been tentatively identified as metabolites III, VII, VIII, XI, XII, on the basis of gas chromatography retention time and gas chromatography-mass spectrometry analysis. Based on these results, a probable mechanism for the formation of p-cresol from piperitenone (I) via the intermediacy of metabolite III has been proposed.

Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, and Carvacrol
International Journal of Toxicology, January 1, 2006; 25(1_suppl): 29 - 127.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
Q. Zhang, P. Ma, M. Iszard, R. B. Cole, W. Wang, and G. Wang
In Vitro Metabolism of R(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a Cannabinoid Receptor Agonist
Drug Metab. Dispos., October 1, 2002; 30(10): 1077 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
L.-J. Chen, E. H. Lebetkin, and L. T. Burka
Metabolism of (R)-(+)-Pulegone in F344 Rats
Drug Metab. Dispos., December 1, 2001; 29(12): 1567 - 1577.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
H. V. Thulasiram, V. B. Bhat, and M. K. Madyastha
Effect of Ring Size in R-(+)-Pulegone-Mediated Hepatotoxicity: Studies on the Metabolism of R-(+)-4-Methyl-2-(1-Methylethylidene)-Cyclopentanone and DL-Camphorone in Rats
Drug Metab. Dispos., June 1, 2001; 29(6): 821 - 829.
[Abstract] [Full Text]

Home page
 Drug Metab. Dispos.Home page
H. V. Thulasiram, A. K. Gadad, and M. K. Madyastha
Role of C-5 Chiral Center in R-(+)-Pulegone-Mediated Hepatotoxicity: Metabolic Disposition and Toxicity of 5,5-Dimethyl-2-(1-Methylethylidene)-Cyclohexanone in Rats
Drug Metab. Dispos., July 1, 2000; 28(7): 833 - 844.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1999 by the American Society for Pharmacology and Experimental Therapeutics.