Vol. 29, Issue 11, 1366-1376, November 2001

SYMPOSIUM REPORT
Cytochromes P450 and Flavin MonooxygenasesTargets and Sources of Nitric Oxide

Edward T. Morgan, Volker Ullrich, Andreas Daiber, Patrick Schmidt, Naoki Takaya, Hirofumi Shoun, John C. McGiff, Adebayo Oyekan, Craig J. Hanke, William B. Campbell, Chang-Shin Park, Ju-Seop Kang, Hyeon-Gyu Yi, Young-Nam Cha, Daniel Mansuy, and Jean-Luc Boucher

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (E.T.M.); Department of Biology, University of Konstanz, Konstanz, Germany (V.U., A.D., P.S.); Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan (N.T.); Department of Biotechnology, University of Tokyo, Tokyo, Japan (H.S.); Department of Pharmacology, New York Medical College, Valhalla, New York (J.C.McG.); Center for Cardiovascular Diseases, Texas Southern University, Houston, Texas (A.O.); Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin (C.J.H., W.B.C); Department of Pharmacology and Toxicology, Inha University, Incon, Korea (C.S.P., H.G.Y., Y.N.C.); Department of Pharmacology, Hanyang University, Seoul, Korea (J.S.K.); and UMR 8601 Centre National de la Recherche Scientifique, University of Paris V, Paris, France (D.M., J.-L. B.).

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 01 meeting in Orlando, FL. The presentations addressed the mechanisms of inhibition and regulation of cytochrome P450 and flavin monooxygenase enzymes by nitric oxide. They also highlighted the consequences of these effects on metabolism of drugs and volatile amines as well as on important physiological parameters, such as control of blood pressure, renal ion transport, and steroidogenesis. This is achieved via regulation of P450-dependent prostacyclin, hydroxyeicosatetraenoic acid, and epoxyeicosatrienoic acid formation. Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed.