Vol. 29, Issue 4, 606-610, April 2001

Interethnic Variability in Human Drug Responses

D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq, and A. Mobarek

Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia (D.A.P.E., M.T., A.M.); and the University of Aberdeen, Aberdeen, United Kingdom (H.L.M., S.P.)

The scientific study of interethnic differences in responses to drugs has been extant for 80 years. Many of these differences have been described at the phenotypic level, and some have been explained by genetic factors. However, it is frequently difficult to disentangle accurately the hereditary and environmental influences in phenotypic comparisons. This is where the recent developments in knowledge of the genes responsible for drug receptors are starting to make a big impact. The beta 2 adrenoceptor is described; it has three genetic polymorphisms. The different genotypes influence responses to agonists such as albuterol (Salbutamol). New gene frequency data including those for Saudi Arabians, Indians, and Africans are shown. The expanding body of knowledge about genetic (and interethnic) variability in drug receptors is likely to be important in clinical medicine.