DMD Simcyp

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meng, X.
Right arrow Articles by Yang, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meng, X.
Right arrow Articles by Yang, C. S.

Vol. 29, Issue 6, 789-793, June 2001

SHORT COMMUNICATION
Formation and Identification of 4'-O-Methyl-(-)-Epigallocatechin in Humans

Xiaofeng Meng, Mao-Jung Lee, Chuan Li, Shuqun Sheng, Nanqun Zhu, Shengmin Sang, Chi-Tang Ho, and Chung S. Yang

Laboratory for Cancer Research
(X.M., M.-J.L., C.L., C.S.Y.),
Department of Chemistry (S.Sh.),
and Department of Food Science
(N.Z., S.Sa., C.-T.H.), Rutgers,
The State University of New Jersey,
Piscataway, New Jersey

The possible beneficial effects of tea consumption have attracted a great deal of attention. Many of the biological effects have been attributed to tea catechins, but the metabolic fate of these compounds is not clear. In the present study, a major metabolite observed in human blood and urine samples after green tea administration was identified as a O-methylated derivative of (-)-epigallocatechin (EGC) by comparison with products from chemical and enzymatic O-methylation of EGC. The structure of this metabolite was elucidated as 4'-O-methyl-(-)-epigallocatechin (4'-O-MeEGC) by 1H and 13C NMR and heteronuclear multiple bond connectivity experiment. The human plasma level of 4'-O-MeEGC reached its peak value within the first 2 h following tea ingestion. Its maximum concentration was 4 to 6 times higher than that of EGC. The half-lives of EGC and 4'-O-MeEGC in the blood were 1.02 ± 0.07 and 4.39 ± 1.14 h, respectively. The amount of 4'-O-MeEGC excreted in urine was about 3 times higher than that of EGC, and 88% of 4'-O-MeEGC was excreted in urine within 8 h. The present structural information and concentration-time profile of this metabolite provide the basis for understanding the biotransformation of EGC and for future elucidation of its biological activities.

Copyright © 2001 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 J. Nutr.Home page
C. Auger, W. Mullen, Y. Hara, and A. Crozier
Bioavailability of Polyphenon E Flavan-3-ols in Humans with an Ileostomy
J. Nutr., August 1, 2008; 138(8): 1535S - 1542S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. Fang, D. Chen, and C. S. Yang
Dietary Polyphenols May Affect DNA Methylation
J. Nutr., January 1, 2007; 137(1): 223S - 228S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Remesy
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 230S - 242S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
P. A Kroon, M. N Clifford, A. Crozier, A. J Day, J. L Donovan, C. Manach, and G. Williamson
How should we assess the effects of exposure to dietary polyphenols in vitro?
Am. J. Clinical Nutrition, July 1, 2004; 80(1): 15 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. Manach, A. Scalbert, C. Morand, C. Remesy, and L. Jimenez
Polyphenols: food sources and bioavailability
Am. J. Clinical Nutrition, May 1, 2004; 79(5): 727 - 747.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
B. Frei and J. V. Higdon
Antioxidant Activity of Tea Polyphenols In Vivo: Evidence from Animal Studies
J. Nutr., October 1, 2003; 133(10): 3275S - 3284.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
H. Lu, X. Meng, and C. S. Yang
Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (-)-Epigallocatechin Gallate
Drug Metab. Dispos., May 1, 2003; 31(5): 572 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
H. Lu, X. Meng, C. Li, S. Sang, C. Patten, S. Sheng, J. Hong, N. Bai, B. Winnik, C.-T. Ho, et al.
Glucuronides of Tea Catechins: Enzymology of Biosynthesis and Biological Activities
Drug Metab. Dispos., April 1, 2003; 31(4): 452 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M.-J. Lee, P. Maliakal, L. Chen, X. Meng, F. Y. Bondoc, S. Prabhu, G. Lambert, S. Mohr, and C. S. Yang
Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and (-)-Epigallocatechin-3-gallate by Humans: Formation of Different Metabolites and Individual Variability
Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 1025 - 1032.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2001 by the American Society for Pharmacology and Experimental Therapeutics.