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Vol. 30, Issue 4, 363-364, April 2002

SHORT COMMUNICATION
Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5'-Untranslated Region and Exon 28

Masaya Itoda, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Norie Murayama, Seiichi Ishida, Kimie Sai, Michiyo Nagano, Hiroshi Suzuki, Yuichi Sugiyama, Shogo Ozawa, and Jun-ichi Sawada

Project Team for Pharmacogenetics
(M.I., Y.S., A.S., M.S., N.M., S.I., K.S., M.N.,
S.O., J.-i.S.),
Division of Biochemistry and Immunochemistry
(Y.S., J.-i.S.),
Division of Pharmacology
(S.I., S.O.),
Division of Xenobiotic Metabolism and
Disposition (K.S.),
National Institute of Health Sciences,
Setagaya-ku, Tokyo, Japan;
Graduate School of Pharmaceutical Sciences
(H.S., Y.S.),
The University of Tokyo,
Tokyo, Japan

We found nucleotide variability in the 5'-upstream region and exonic sequences of a gene-encoding canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2 (cMOAT/MRP2) by polymerase chain reaction-based sequencing using genomic DNA from 72 established cell lines derived from 72 Japanese individuals. Four single nucleotide polymorphisms (SNPs) were found in the 5'-untranslational region and 21 in the exonic regions. Of them, 14 were nonsynonymous SNPs. One deletion of seven consecutive adenines resulting in a frameshift variant was also found. Four SNPs, c-24t, g1249a (V417I), c2366t (S789F), and c3972t (I1324I), were the same as those recently reported. A strong association was found between c-24t (5'-untranslated region) and c3972t (exon 28), with the promoter activity of the former worth being compared.

Copyright © 2002 by The American Society for Pharmacology and Experimental Therapeutics


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Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics.