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Vol. 30, Issue 5, 488-493, May 2002
Biomedical Research Institute (T.S.) and Laboratory of Biomedical
Pharmacology and Toxicology (M.H., T.S.), Chiba University, Chiba,
Japan; Department of Pharmacology, University of California at San
Diego (P.T.), La Jolla, California; Department of Biochemistry and
Molecular Biology, Indiana University School of Medicine (W.F.B.,
S.P.S.), Indianapolis, Indiana; Department of Pharmacology, University
of Michigan School of Medicine (B.N.L.D.), Ann Arbor, Michigan
This article reports on a symposium sponsored by the American
Society for Pharmacology and Experimental Therapeutics and held at the
April 2001 Experimental Biology meeting. Current developments in
molecular-based studies into the structure and function of cholinesterases, carboxylesterases, and paraoxonases are described. This article covers mechanisms of regulation of gene expression of the
various esterases by developmental factors and xenobiotics, as well as
the interplay between physiological and chemical regulation of enzyme activity.
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