![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 30, Issue 5, 488-493, May 2002
Biomedical Research Institute (T.S.) and Laboratory of Biomedical
Pharmacology and Toxicology (M.H., T.S.), Chiba University, Chiba,
Japan; Department of Pharmacology, University of California at San
Diego (P.T.), La Jolla, California; Department of Biochemistry and
Molecular Biology, Indiana University School of Medicine (W.F.B.,
S.P.S.), Indianapolis, Indiana; Department of Pharmacology, University
of Michigan School of Medicine (B.N.L.D.), Ann Arbor, Michigan
This article reports on a symposium sponsored by the American
Society for Pharmacology and Experimental Therapeutics and held at the
April 2001 Experimental Biology meeting. Current developments in
molecular-based studies into the structure and function of cholinesterases, carboxylesterases, and paraoxonases are described. This article covers mechanisms of regulation of gene expression of the
various esterases by developmental factors and xenobiotics, as well as
the interplay between physiological and chemical regulation of enzyme activity.
This article has been cited by other articles:
|
|
 |
|
  S. Takahashi, M. Katoh, T. Saitoh, M. Nakajima, and T. Yokoi Different Inhibitory Effects in Rat and Human Carboxylesterases Drug Metab. Dispos., May 1, 2009; 37(5): 956 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sjodin, H. Fritsch, U. G. Eriksson, U. Logren, A. Nordgren, P. Forsell, L. Knutson, and H. Lennernas Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs Drug Metab. Dispos., August 1, 2008; 36(8): 1519 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Williams, K. O. Jones, G. D. Ponsler, S. M. Lowery, E. J. Perkins, S. A. Wrighton, K. J. Ruterbories, M. Kazui, and N. A. Farid The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2 Drug Metab. Dispos., July 1, 2008; 36(7): 1227 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita, A. Yamamoto, and Y. Sugiyama P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier Drug Metab. Dispos., February 1, 2008; 36(2): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Schiel, S.-l. Green, W. I. Davis, P. C. Sanghani, W. F. Bosron, and S. P. Sanghani Expression and Characterization of a Human Carboxylesterase 2 Splice Variant J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-R. Kim, K. Sai, T. Tanaka-Kagawa, H. Jinno, S. Ozawa, N. Kaniwa, Y. Saito, A. Akasawa, K. Matsumoto, H. Saito, et al. Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population Drug Metab. Dispos., October 1, 2007; 35(10): 1865 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Imai, M. Taketani, M. Shii, M. Hosokawa, and K. Chiba Substrate Specificity of Carboxylesterase Isozymes and Their Contribution to Hydrolase Activity in Human Liver and Small Intestine Drug Metab. Dispos., October 1, 2006; 34(10): 1734 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Godin, E. J. Scollon, M. F. Hughes, P. M. Potter, M. J. DeVito, and M. K. Ross Species Differences in the in Vitro Metabolism of Deltamethrin and Esfenvalerate: Differential Oxidative and Hydrolytic Metabolism by Humans and Rats Drug Metab. Dispos., October 1, 2006; 34(10): 1764 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Polsky-Fisher, H. Cao, P. Lu, and C. R. Gibson EFFECT OF CYTOCHROMES P450 CHEMICAL INHIBITORS AND MONOCLONAL ANTIBODIES ON HUMAN LIVER MICROSOMAL ESTERASE ACTIVITY Drug Metab. Dispos., August 1, 2006; 34(8): 1361 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Zhang, S. S. Dehal, T. Ho, J. Johnson, C. Chandler, A. P. Blanchard, R. J. Clark Jr., C. L. Crespi, D. M. Stresser, and J. Wong HUMAN CYTOCHROME P450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE H152/81 Drug Metab. Dispos., May 1, 2006; 34(5): 734 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakamura, Y. Kawakita, A. Yasuhara, Y. Fukasawa, K. Yoshida, K. Sakagami, and A. Nakazato IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST Drug Metab. Dispos., March 1, 2006; 34(3): 369 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Landowski, P. L. Lorenzi, X. Song, and G. L. Amidon Nucleoside Ester Prodrug Substrate Specificity of Liver Carboxylesterase J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 572 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, S.-R. Kim, K. Sai, Y. Saito, T. Nakajima, K. Matsumoto, H. Saito, K. Shirao, N. Yamamoto, H. Minami, et al. FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2) Drug Metab. Dispos., October 1, 2005; 33(10): 1482 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Imai, M. Imoto, H. Sakamoto, and M. Hashimoto IDENTIFICATION OF ESTERASES EXPRESSED IN CACO-2 CELLS AND EFFECTS OF THEIR HYDROLYZING ACTIVITY IN PREDICTING HUMAN INTESTINAL ABSORPTION Drug Metab. Dispos., August 1, 2005; 33(8): 1185 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fujikawa, T. Satoh, A. Suganuma, S. Suzuki, Y. Niikura, S. Yui, and Y. Yamaura Extremely sensitive biomarker of acute organophosphorus insecticide exposure Human and Experimental Toxicology, June 1, 2005; 24(6): 333 - 336. [Abstract] [PDF]
|
|
|
|
|
|
S. K. Quinney, S. P. Sanghani, W. I. Davis, T. D. Hurley, Z. Sun, D. J. Murry, and W. F. Bosron Hydrolysis of Capecitabine to 5'-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Landowski, B. S. Vig, X. Song, and G. L. Amidon Targeted delivery to PEPT1-overexpressing cells: Acidic, basic, and secondary floxuridine amino acid ester prodrugs Mol. Cancer Ther., April 1, 2005; 4(4): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Walsky, E. A. Gaman, and R. S. Obach Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8 J. Clin. Pharmacol., January 1, 2005; 45(1): 68 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Furihata, M. Hosokawa, N. Koyano, T. Nakamura, T. Satoh, and K. Chiba IDENTIFICATION OF DI-(2-ETHYLHEXYL) PHTHALATE-INDUCED CARBOXYLESTERASE 1 IN C57BL/6 MOUSE LIVER MICROSOMES: PURIFICATION, CDNA CLONING, AND BACULOVIRUS-MEDIATED EXPRESSION Drug Metab. Dispos., October 1, 2004; 32(10): 1170 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Sun, D. J. Murry, S. P. Sanghani, W. I. Davis, N. Y. Kedishvili, Q. Zou, T. D. Hurley, and W. F. Bosron Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1 J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 469 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Sanghani, S. K. Quinney, T. B. Fredenburg, W. I. Davis, D. J. Murry, and W. F. Bosron HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3 Drug Metab. Dispos., May 1, 2004; 32(5): 505 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Sanghani, S. K. Quinney, T. B. Fredenburg, Z. Sun, W. I. Davis, D. J. Murry, O. W. Cummings, D. E. Seitz, and W. F. Bosron Carboxylesterases Expressed in Human Colon Tumor Tissue and Their Role in CPT-11 Hydrolysis Clin. Cancer Res., October 15, 2003; 9(13): 4983 - 4991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kim, X.-y. Chu, S. Kim, C. J. Provoda, K.-D. Lee, and G. L. Amidon Identification of a Human Valacyclovirase: BIPHENYL HYDROLASE-LIKE PROTEIN AS VALACYCLOVIR HYDROLASE J. Biol. Chem., July 3, 2003; 278(28): 25348 - 25356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Laizure, T. Mandrell, N. M. Gades, and R. B. Parker Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases Drug Metab. Dispos., January 1, 2003; 31(1): 16 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xie, D. Yang, M. Wu, B. Xue, and B. Yan Mouse Liver and Kidney Carboxylesterase (M-LK) Rapidly Hydrolyzes Antitumor Prodrug Irinotecan and the N-Terminal Three Quarter Sequence Determines Substrate Selectivity Drug Metab. Dispos., January 1, 2003; 31(1): 21 - 27. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
