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Faculty of Pharmacy and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada (P.G.W., P.M.K.); Department of Clinical Pharmacology, Flinders Medical Centre, Adelaide, South Australia, Australia (P.I.M., P.A.G., A.J.H.); Graduate School of Pharmaceutical Sciences, Kyushu University (Y.I.), Fukuoka-shi, Kyushu, Japan; Albert Einstein College of Medicine, Yeshiva University, Bronx, New York (J.R.C., N.R.C.); Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada (C.G.); and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia (J.K.R., F.K.K.)
Abstract
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
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