![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Faculty of Pharmacy and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada (P.G.W., P.M.K.); Department of Clinical Pharmacology, Flinders Medical Centre, Adelaide, South Australia, Australia (P.I.M., P.A.G., A.J.H.); Graduate School of Pharmaceutical Sciences, Kyushu University (Y.I.), Fukuoka-shi, Kyushu, Japan; Albert Einstein College of Medicine, Yeshiva University, Bronx, New York (J.R.C., N.R.C.); Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada (C.G.); and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia (J.K.R., F.K.K.)
Abstract
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
This article has been cited by other articles:
|
|
 |
|
  T. Izukawa, M. Nakajima, R. Fujiwara, H. Yamanaka, T. Fukami, M. Takamiya, Y. Aoki, S.-i. Ikushiro, T. Sakaki, and T. Yokoi Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers Drug Metab. Dispos., August 1, 2009; 37(8): 1759 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Itaaho, M. H. Court, P. Uutela, R. Kostiainen, A. Radominska-Pandya, and M. Finel Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10 Drug Metab. Dispos., April 1, 2009; 37(4): 768 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ohno and S. Nakajin Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction Drug Metab. Dispos., January 1, 2009; 37(1): 32 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Siissalo, H. Zhang, E. Stilgenbauer, A. M. Kaukonen, J. Hirvonen, and M. Finel The Expression of Most UDP-Glucuronosyltransferases (UGTs) Is Increased Significantly during Caco-2 Cell Differentiation, whereas UGT1A6 Is Highly Expressed Also in Undifferentiated Cells Drug Metab. Dispos., November 1, 2008; 36(11): 2331 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Itaaho, P. I. Mackenzie, S.-i. Ikushiro, J. O. Miners, and M. Finel The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of {beta}-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases Drug Metab. Dispos., November 1, 2008; 36(11): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Basu, L. Kole, M. Basu, K. Chakraborty, P. S. Mitra, and I. S. Owens The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C J. Biol. Chem., August 22, 2008; 283(34): 23048 - 23061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kaivosaari, P. Toivonen, O. Aitio, J. Sipila, M. Koskinen, J. S. Salonen, and M. Finel Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes Drug Metab. Dispos., August 1, 2008; 36(8): 1529 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Kondraganti, W. Jiang, A. K. Jaiswal, and B. Moorthy Persistent Induction of Hepatic and Pulmonary Phase II Enzymes by 3-Methylcholanthrene in Rats Toxicol. Sci., April 1, 2008; 102(2): 337 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Falkner, J. K. Ritter, and R. A. Prough Regulation of the Rat UGT1A6 by Glucocorticoids Involves a Cryptic Glucocorticoid Response Element Drug Metab. Dispos., February 1, 2008; 36(2): 409 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kaivosaari, P. Toivonen, L. M. Hesse, M. Koskinen, M. H. Court, and M. Finel Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10 Mol. Pharmacol., September 1, 2007; 72(3): 761 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhang, L. Wang, G. Chandrasena, L. Ma, M. Zhu, H. Zhang, C. D. Davis, and W. G. Humphreys Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar Drug Metab. Dispos., January 1, 2007; 35(1): 139 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Tallman, K. K. Miles, F. K. Kessler, J. N. Nielsen, X. Tian, J. K. Ritter, and P. C. Smith The Contribution of Intestinal UDP-Glucuronosyltransferases in Modulating 7-Ethyl-10-hydroxy-camptothecin (SN-38)-Induced Gastrointestinal Toxicity in Rats J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 29 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, S. Chen, X. Li, X. Wang, and S. Zeng Genetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han Population Drug Metab. Dispos., September 1, 2006; 34(9): 1462 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sten, S. Qvisen, P. Uutela, L. Luukkanen, R. Kostiainen, and M. Finel Prominent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10 Drug Metab. Dispos., September 1, 2006; 34(9): 1488 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Richardson, M. Sherman, D. Kalman, and E. T. Morgan EXPRESSION OF UDP-GLUCURONOSYLTRANSFERASE ISOFORM mRNAS DURING INFLAMMATION AND INFECTION IN MOUSE LIVER AND KIDNEY Drug Metab. Dispos., March 1, 2006; 34(3): 351 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Finel, X. Li, D. Gardner-Stephen, S. Bratton, P. I. Mackenzie, and A. Radominska-Pandya Human UDP-Glucuronosyltransferase 1A5: Identification, Expression, and Activity J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1143 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Cloughesy, J. Kuhn, H. I. Robins, L. Abrey, P. Wen, K. Fink, F. S. Lieberman, M. Mehta, S. Chang, A. Yung, et al. Phase I Trial of Tipifarnib in Patients With Recurrent Malignant Glioma Taking Enzyme-Inducing Antiepileptic Drugs: A North American Brain Tumor Consortium Study J. Clin. Oncol., September 20, 2005; 23(27): 6647 - 6656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Di Marco, M. D'Antoni, S. Attaccalite, P. Carotenuto, and R. Laufer DETERMINATION OF DRUG GLUCURONIDATION AND UDP-GLUCURONOSYLTRANSFERASE SELECTIVITY USING A 96-WELL RADIOMETRIC ASSAY Drug Metab. Dispos., June 1, 2005; 33(6): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liu, F. Innocenti, M. J. Ratain, N. Kato, Y. Wang, and M. Omata Linkage Disequilibrium across the UGT1A Locus Should Not Be Ignored in Association Studies of Cancer Susceptibility Clin. Cancer Res., February 1, 2005; 11(3): 1348 - 1349. [Full Text] [PDF]
|
|
|
|
|
|
J. J. McElwee, E. Schuster, E. Blanc, J. H. Thomas, and D. Gems Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance J. Biol. Chem., October 22, 2004; 279(43): 44533 - 44543. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
