![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, 889-1692, Japan
There has been very limited information on the capacities of tropical fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical fruits on midazolam 1'-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical fruits such as common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit were tested. We also examined the inhibition of CYP3A activity by grapefruit (white) and Valencia orange as controls. The juice of star fruit showed the most potent inhibition of CYP3A. The addition of a star fruit juice (5.0%, v/v) resulted in the almost complete inhibition of midazolam 1'-hydroxylase activity (residual activity of 0.1%). In the case of grape-fruit, the residual activity was 14.7%. The inhibition depended on the amount of fruit juice added to the incubation mixture (0.2–6.0%, v/v). The elongation of the preincubation period of a juice from star fruit (1.25 or 2.5%, v/v) with the microsomal fraction did not alter the CYP3A inhibition, suggesting that the star fruit did not contain a mechanism-based inhibitor. Thus, we discovered filtered extracts of star fruit juice to be inhibitors of human CYP3A activity in vitro.
This article has been cited by other articles:
|
|
 |
|
  R. J. Baumann Salivary Monitoring of Antiepileptic Drugs Journal of Pharmacy Practice, April 1, 2007; 20(2): 147 - 157. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Farkas, L. E. Oleson, Y. Zhao, J. S. Harmatz, M. A. Zinny, M. H. Court, and D. J. Greenblatt Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450-3A Activity: Comparison With Grapefruit Juice J. Clin. Pharmacol., March 1, 2007; 47(3): 286 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nagata, M. Hidaka, H. Sekiya, Y. Kawano, K. Yamasaki, M. Okumura, and K. Arimori Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats Drug Metab. Dispos., February 1, 2007; 35(2): 302 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M Summers Potential Drug-Food Interactions with Pomegranate Juice Ann. Pharmacother., July 1, 2006; 40(7): 1472 - 1473. [Full Text] [PDF]
|
|
|
|
|
|
H. Kim, Y.-J. Yoon, J.-H. Shon, I.-J. Cha, J.-G. Shin, and K.-H. Liu INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY Drug Metab. Dispos., April 1, 2006; 34(4): 521 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hidaka, M. Okumura, T. Ogikubo, H. Kai, K.-I. Fujita, T. Iwakiri, K. Yamasaki, N. Setoguchi, N. Matsunaga, and K. Arimori TRANSIENT INHIBITION OF CYP3A IN RATS BY STAR FRUIT JUICE Drug Metab. Dispos., March 1, 2006; 34(3): 343 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hidaka, M. Okumura, K.-i. Fujita, T. Ogikubo, K. Yamasaki, T. Iwakiri, N. Setoguchi, and K. Arimori EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS Drug Metab. Dispos., May 1, 2005; 33(5): 644 - 648. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
