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Drug Metabolism and Disposition Fast Forward
First published on February 11, 2005; DOI: 10.1124/dmd.104.003301

0090-9556/05/3305-619-622$20.00
DMD 33:619-622, 2005

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SHORT COMMUNICATION

POSSIBLE INVOLVEMENT OF ORGANIC ANION TRANSPORTER 2 ON THE INTERACTION OF THEOPHYLLINE WITH ERYTHROMYCIN IN THE HUMAN LIVER

Yasuna Kobayashi, Ryoko Sakai, Naomi Ohshiro, Masayuki Ohbayashi, Noriko Kohyama, and Toshinori Yamamoto

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan (Y.K., R.S., M.O., N.K., T.Y.); and Department of Physiology and Biophysics, the University of Texas Medical Branch at Galveston, Galveston, Texas (N.O.)

Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human Oat2 (hOat2) have been elucidated, a possible involvement of hOat2 in drug interaction is less defined. The purpose of this study was to investigate the interaction of theophylline with erythromycin mediated by hOat2 using a Xenopus laevis oocyte expression system. When expressed in Xenopus oocytes, hOat2 mediated the transport of theophylline and erythromycin. The finding indicates that the two compounds are novel substrates for hOat2. The apparent Km values for the uptake of hOat2 that mediated the transport of theophylline and erythromycin were 12.6 µM and 18.5 µM, respectively. The hOat2-mediated uptake of [14C]theophylline and [14C]erythromycin was cis-inhibited by adding erythromycin and theophylline, respectively. Our present findings suggest that hOat2 may, at least in part, be involved in the theophylline-erythromycin interaction in the human liver.

Address correspondence to: Dr. Toshinori Yamamoto, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555. E-mail: yamagen{at}pharm.showa-u.ac.jp




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Drug Metab. Dispos., August 1, 2008; 36(8): 1519 - 1528.
[Abstract] [Full Text] [PDF]


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