![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas
Organic anion-transporting polypeptides (Oatps) are Na+-independent solute carriers for cellular uptake of organic compounds. The purpose of this study is to determine 1) the constitutive mRNA expression of the 15 mouse Oatp genes in 12 tissues, 2) whether there are gender differences in Oatp expression, and 3) the ontogenic expression of Oatps in liver and kidney. The mRNA expression of the 15 mouse Oatps was quantified using the branched DNA technique. Oatp1a1, 1a4, 1b2, and 2b1 are expressed in liver at relatively high levels, with Oatp1b2 being exclusively expressed in liver. Oatp1a1, 1a6, 3a1, and 4c1 are highly expressed in kidney. Oatp1a4 and 1c1 are highly expressed in brain. Oatp1a5, 6b1, 6c1, and 6d1 are predominant in testes. Oatp2a1, 4a1, and 5a1 are predominantly expressed in placenta. In liver, expression of Oatp1a1 was male-predominant, whereas expression of Oatp1a4 and 1a6 was female-predominant. In kidney, expression of Oatp1a1, 3a1, and 4c1 was higher in males than in females. Hepatic expression of Oatp1a1, 1a4, 1a6, 1b2, and 2b1 gradually increased after birth and reached adult levels by 6 weeks of age. Only Oatp2a1 was expressed at adult levels at birth. In kidney, expression of mouse Oatp1a1, 1a6, and 3a1 was lower at birth than at 6 weeks of age, whereas expression of mouse Oatp1a4, 2a1, and 2b1 was similar at birth and at 6 weeks of age. These data on the tissue distribution and ontogenic expression of mouse Oatps will aid in understanding the pharmacokinetics and toxicokinetics of drugs and other chemicals.
This article has been cited by other articles:
|
|
 |
|
  X. Cheng and C. D. Klaassen Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys Drug Metab. Dispos., November 1, 2009; 37(11): 2178 - 2185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vetrugno, M. A. Di Bari, R. Nonno, M. Puopolo, C. D'Agostino, L. Pirisinu, M. Pocchiari, and U. Agrimi Oral pravastatin prolongs survival time of scrapie-infected mice J. Gen. Virol., July 1, 2009; 90(7): 1775 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Cui, L. M. Aleksunes, Y. Tanaka, M. J. Goedken, and C. D. Klaassen Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice Toxicol. Sci., July 1, 2009; 110(1): 47 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. J. Zhang, R. L. Yeager, and C. D. Klaassen Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver Drug Metab. Dispos., January 1, 2009; 37(1): 106 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng and C. D. Klaassen Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR-{alpha} and CAR Transcription Factors Toxicol. Sci., November 1, 2008; 106(1): 29 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng and C. D. Klaassen Critical Role of PPAR-{alpha} in Perfluorooctanoic Acid- and Perfluorodecanoic Acid-Induced Downregulation of Oatp Uptake Transporters in Mouse Livers Toxicol. Sci., November 1, 2008; 106(1): 37 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, J. L. Stock, X. Liu, J. Shi, J. W. Van Deusen, D. A. DiMattia, R. G. Dullea, and S. M. de Morais Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds Drug Metab. Dispos., September 1, 2008; 36(9): 1840 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Aleksunes, Y. Cui, and C. D. Klaassen Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta Drug Metab. Dispos., September 1, 2008; 36(9): 1960 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Evers and X.-Y. Chu Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity Mol. Pharmacol., August 1, 2008; 74(2): 309 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lu, S. Choudhuri, K. Ogura, I. L. Csanaky, X. Lei, X. Cheng, P.-z. Song, and C. D. Klaassen Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR Toxicol. Sci., May 1, 2008; 103(1): 35 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Clark, M. A. Davis, T. P. Ryan, G. H. Searfoss, and S. B. Hooser Hepatic Gene Expression Changes in Mice Associated with Prolonged Sublethal Microcystin Exposure Toxicol Pathol, June 1, 2007; 35(4): 594 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, X. Cheng, M. Z. Dieter, Y. Tanaka, and C. D. Klaassen Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression Mol. Pharmacol., April 1, 2007; 71(4): 1159 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lickteig, A. L. Slitt, M. C. Arkan, M. Karin, and N. J. Cherrington Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-{alpha}, Interleukin-1{beta}, Interleukin-6, and Nuclear Factor-{kappa}B in Two Models of Cholestasis Drug Metab. Dispos., March 1, 2007; 35(3): 402 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng and C. D. Klaassen Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine Drug Metab. Dispos., November 1, 2006; 34(11): 1863 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng, J. Maher, H. Lu, and C. D. Klaassen Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression Mol. Pharmacol., October 1, 2006; 70(4): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Staskal, J. J. Diliberto, and L. S. Birnbaum Disposition of BDE 47 in Developing Mice Toxicol. Sci., April 1, 2006; 90(2): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Goralski, P. D. Acott, A. D. Fraser, D. Worth, and C. J. Sinal BRAIN CYCLOSPORIN A LEVELS ARE DETERMINED BY ONTOGENIC REGULATION OF MDR1A EXPRESSION Drug Metab. Dispos., February 1, 2006; 34(2): 288 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng, J. Maher, M. Z. Dieter, and C. D. Klaassen REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYS Drug Metab. Dispos., September 1, 2005; 33(9): 1276 - 1282. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
