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Urinary metabolites of amitriptyline in the dog

HB Hucker, AJ Balletto, J Demetriades, BH Arison and AG Zacchei

Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine was 10- hydroxyamitriptyline, excreted mainly in conjugated form. Other metabolites were characterized as 10-hydroxynortriptyline, amitriptyline N-oxide, and nortriptyline. Together, these metabolites accounted for approximately 47% of the urinary radioactivity.

Volume 5, Issue 2, pp. 132-142, 03/01/1977
Copyright © 1977 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics.