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Metabolism of cyclobenzaprine in the dog

HB Hucker, AJ Balletto, BH Arison and AG Zacchei

Ten metabolites of cyclobenzaprine, accounting for approximately 50% of the urinary radioactivity, were identified in the urine of dogs to which the labeled drug had been given orally. These included the 1,2- dihydrodiol, three phenolic derivatives, the N-oxide, the 10,11- epoxide, the 10,11-glycol, desmethylcyclobenzaprine, and the glucuronide conjugates of desmethylcyclobenzaprine and cyclobenzaprine. The metabolites were excreted in both the free and conjugated states. Unchanged cyclobenzaprine was present in only minor amounts.

Volume 6, Issue 2, pp. 184-192, 03/01/1978
Copyright © 1978 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics.