Received for publication February 19, 2008.
Revised February 27, 2008.
Accepted for publication February 27, 2008.

The development of drug metabolism research as expressed in the publications of ASPET Part 2-1959-1983

Abstract

In 25 years drug metabolism research went from using sub cellular particles of undefined content to an understanding of metabolism at the molecular level. The discovery of cytochrome P450, enzyme induction, reactive intermediates, and genetic polymorphisms provided milestones in the field. New publications from ASPET chronicled the discoveries and provided communications to advance the science of drug metabolism.

Key words: cytochrome P450, cytochrome P450 catalyzed oxidations, drug disposition, human CYP enzymes, mechanism-based inhibition, p-glycoprotein, pharmacogenomics, polymorphisms