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Erratum for Schwab and Pang, Drug Metab Dispos 27 (6) 746-755.
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Vol. 30, Issue 11, 1296-1296, November 2002

ERRATUM

Correction to "The Multiple Indicator-Dilution Method for the Study of Enzyme Heterogeneity in Liver: Theoretical Basis"

Drug Metabolism and Disposition 27: 746

In the above article [Schwab AJ and Pang KS (1999) Drug Metab Dispos 27:746-755], two equations were incorrect. On page 750, equations 24 and 25 should be:
<UP>MTT<SUB>M</SUB> = </UP><FR><NU>(<UP>MTT<SUB>M,pp</SUB> + MTT<SUB>PM,pv</SUB></UP>)<UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB></UP></NU><DE><UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB> + AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></DE></FR><UP> + </UP><FR><NU>(<UP>MTT<SUB>pp</SUB> + MTT<SUB>M,pv</SUB></UP>)<UP>AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></NU><DE><UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB> + AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></DE></FR> (24)

<AR><R><C><UP>VTT<SUB>M</SUB> = </UP><FR><NU>(<UP>VTT<SUB>M,pp</SUB> + VTT<SUB>PM,pv</SUB></UP>)<UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB></UP></NU><DE><UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB> + AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></DE></FR><UP> + </UP><FR><NU>(<UP>VTT<SUB>pp</SUB> + VTT<SUB>M,pv</SUB></UP>)<UP>AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></NU><DE><UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB> + AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></DE></FR></C></R><R><C><UP> + </UP><FR><NU>(<UP>MTT<SUB>M,pp</SUB> + MTT<SUB>PM,pv</SUB> − MTT<SUB>pp</SUB> − MTT<SUB>M,pv</SUB></UP>)<SUP><UP>2</UP></SUP><UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB>AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP></NU><DE>(<UP>AUC<SUB>M,pp</SUB>AUC<SUB>PM,pv</SUB> + AUC<SUB>pp</SUB>AUC<SUB>M,pv</SUB></UP>)<SUP><UP>2</UP></SUP></DE></FR></C></R></AR> (25)
The calculations were based on the correct equations and not on the previously published equations. The authors regret any confusion or inconvenience this error may have caused.

0090-9556/02/3011-1296-1296
DMD, 30:1296-1296, 2002
Copyright © 2002 by The American Society for Pharmacology and Experimental Therapeutics



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