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Erratum for Xiang et al., Drug Metab Dispos 32 (11) 1230-1238.
0090-9556/05/3301-200-201$20.00
DMD 33:200-201, 2005

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ERRATUM

CORRECTION TO "TISSUE DISTRIBUTION, STABILITY, AND PHARMACOKINETICS OF APO2 LIGAND/TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND IN HUMAN COLON CARCINOMA COLO205 TUMOR-BEARING MICE"

In the above article [Xiang H, Nguyen CB, Kelley SK, Dybdal N, and Escandón E (2004) Drug Metab Dispos 32:1230-1238], the wrong Figs. 2, 3, 5, 6, 7, and 10 appeared. The correct figures follow. The online version has been corrected in departure from the print version.GoGo



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  		FIG. 2. Recovery of Apo2L/TRAIL in human serum determined by ELISA and an alamarBlue bioassay. Apo2L/TRAIL at 1 µg/ml, 10 µg/ml, and 25 µg/ml was incubated for 0, 1, 2, 4, 8, 24, and 48 h at 37°C with pooled human serum. A, the percentage of Apo2L/TRAIL recovered from human serum by ELISA was normalized to the control group. B, Apo2L/TRAIL bioactivity at different concentrations and time points was compared with the control group.

 


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  		FIG. 3. Concentration versus time profiles for Apo2L/TRAIL. 125I-Apo2L/TRAIL serum concentrations were determined by analysis of TCA-precipitable radioactivity at 5 min, 15 min, 30 min, 1 h, 2 h, and 4 h after administration. Nanogram-equivalents of precipitable 125I-Apo2L/TRAIL were calculated and are shown on the y-axis. Apo2L/TRAIL serum concentrations were analyzed by ELISA. Data are from three mice per time point.

 

We regret any confusion or inconvenience caused by this printing error.

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  		FIG. 5. Nanogram-equivalents of total 125I-Apo2L/TRAIL measured in tissues and tumor. Total radioactivity of 125I-Apo2L/TRAIL in kidney, liver, lung, spleen, tumor, and plasma was measured at 5 min, 15 min, 30 min, 1 h, 2 h, and 4 h after dosing with 125I-Apo2L/TRAIL (A) or 125I-Apo2L/TRAIL plus unlabeled Apo2L/TRAIL (B). Nanogram-equivalents of 125I-Apo2L/TRAIL were calculated as described under Materials and Methods and are shown on the y-axis.

 


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  		FIG. 6. Total 125I-Apo2L/TRAIL in kidney and tumor. Figures represent 125IApo2L/TRAIL radioactivity (cpm/g) in kidney (A) and tumor (B) at 5 min, 15 min, 30 min, 1 h, 2 h, and 4 h after dosing 125I-Apo2L/TRAIL or 125I-Apo2L/TRAIL plus unlabeled Apo2L/TRAIL.

 


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  		FIG. 7. Nanogram-equivalents of TCA-precipitable 125I-Apo2L/TRAIL in tissues and tumor. TCA-precipitable 125I-Apo2L/TRAIL in kidney, liver, lung, spleen, tumor, and plasma were measured at 5 min, 15 min, 30 min, 1 h, 2 h, and 4 h after dosing 125I-Apo2L/TRAIL (A) or 125I-Apo2L/TRAIL plus unlabeled Apo2L/TRAIL (B). Nanogram-equivalents of 125I-Apo2L/TRAIL were calculated and are shown on the y-axis.

 


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  		FIG. 10. Tissue-to-blood ratios of 125I-Apo2L/TRAIL in tissue. Tissue-to-blood ratios of 125I-Apo2L/TRAIL in kidney, liver, blood pool, brain, lung, stomach, and intestine at 15 min and 1 h after dosing with 125I-Apo2L/TRAIL (A) or 125I-Apo2L/TRAIL plus unlabeled Apo2L/TRAIL (B).

 





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