Research ArticleSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Shringi Sharma, Ewa C. S. Ellis, Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Marc Hansel, Donald R. Mattison, Steve N. Caritis, Ronald N. Hines, Raman Venkataramanan and Stephen C. Strom
Drug Metabolism and Disposition February 2013, 41 (2) 296-304; DOI: https://doi.org/10.1124/dmd.112.044891
Shringi Sharma
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Ewa C. S. Ellis
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Roberto Gramignoli
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Kenneth Dorko
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Veysel Tahan
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Marc Hansel
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Donald R. Mattison
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Steve N. Caritis
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Ronald N. Hines
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Raman Venkataramanan
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
Stephen C. Strom
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania (S.S., R.V.); Departments of Clinical Science, Intervention and Technology (E.C.S.E.) and Laboratory Medicine, and Division of Pathology (R.G., S.C.S.), Karolinska Institutet, Stockholm, Sweden; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (K.D., V.T., M.H.); Risk Sciences International and McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada (D.R.M.); Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Women’s Hospital, Pittsburgh, Pennsylvania (S.N.C.); and Department of Pediatrics, Medical College of Wisconsin and Children’s Research Institute, Children’s Hospital and Health System, Milwaukee, Wisconsin (R.N.H.)
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In this issue
Research ArticleSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Expression and Activity of Fetal Hepatic Transporters
Shringi Sharma, Ewa C. S. Ellis, Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Marc Hansel, Donald R. Mattison, Steve N. Caritis, Ronald N. Hines, Raman Venkataramanan and Stephen C. Strom
Drug Metabolism and Disposition February 1, 2013, 41 (2) 296-304; DOI: https://doi.org/10.1124/dmd.112.044891
Research ArticleSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Expression and Activity of Fetal Hepatic Transporters
Shringi Sharma, Ewa C. S. Ellis, Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Marc Hansel, Donald R. Mattison, Steve N. Caritis, Ronald N. Hines, Raman Venkataramanan and Stephen C. Strom
Drug Metabolism and Disposition February 1, 2013, 41 (2) 296-304; DOI: https://doi.org/10.1124/dmd.112.044891
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