This article has 9 data supplements.

Files in this Data Supplement:

• Data Supplement - Table 1. MetaDrug metabolism rules, Table 2. Result of using MetaDrug to generate the first pass metabolites of molecules
• Data Supplement - Figure 1A. Figure 1.Network for OHT with microarray expression data are overlaid on the key proteins involved in drug metabolism…
• Data Supplement - Figure 1B. Network for Artmisinin using PCR data from human hepatocytes…
• Data Supplement - Figure 1C. Network for Artemisinin using Microarray data from the NCI cell lines
• Data Supplement - Figure 2A. Network visualization generated with MetaCoreTM and the Analyze Networks algorithm using microarray expression data overlaid on proteins following human hepatocyte treatment with Trovafloxacin
• Data Supplement - Figure 2B. GO processes highlighted for intracellular signaling cascade on Figure 4A.
• Data Supplement - Figure 3. Figure 3 A. Network visualization generated with MetaCoreTM and the Analyze Networks algorithm using microarray expression data overlaid on proteins following MCF-7 cell treatment with 4- OHT…
• Data Supplement - Figure 4A. Network visualization generated with MetaCoreTM and the Analyze Networks algorithm using microarray expression data overlaid on proteins following cell line treatment with Artemisin analogs…
• Data Supplement - Figure 4B. GO processes highlighted for oxidative stress on Figure 7A