In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids
Drug Metab Dispos Fridén et al.
35: 1711
Data Supplement
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Data Supplement
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Appendix I. Suggested procedures for experimental estimation of unbound drug
concentrations in brain ISF and ICF as well as the unbound brain-to-plasma and ICF-to-ISF
distribution ratios Kp,uu and Kp,uu,cell.