Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model -- Yan et al. 36 (4): 759 Data Supplement - Data Supplement -- Drug Metabolism and Disposition

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Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model
Drug Metab Dispos Yan et al. 36: 759

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Example Calculations. Application of the FCMA was automated. Nevertheless, below we walk through examples of predicting two ISL parameter values for prazosin and propranolol.
TABLE S1. Description of ISL parameters and their values for the simulations in Figs. 5-7 and S3, except where noted otherwise.
Figure S1. Expected outflow profiles for sucrose co-administrated with prazosin and propranolol using predicted parameter values...
TABLE S2. Two sets of predicted ISL parameter values for prazosin and propranolol calculated using the two, different, FCMA-generated, drug-specific prediction strategies illustrated in Fig. S2.
Figure S2. Mappings between PCP subgroups and ISL parameter subgroups (as in Fig.4).
Figure S3. Expected outflow profiles for prazosin and propranolol using predicted parameter values.

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