Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes
Drug Metab Dispos Yoo et al.
36: 485
Data Supplement
Files in this Data Supplement:
Data Supplement
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Supplement 1. M4 formation from M3 in (A) H2O and (B) D2O-medium...
Data Supplement
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Supplement 2. Plot for v (formation velocity of M4) vs concentration of LC15-0133 and the related kinetic parameters...
Data Supplement
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Supplement 3. Extracted ion chromatograms for the samples incubated with rat, human, and dog liver microsomes....
Data Supplement
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Supplement 4. Chemical inhibition study for M5 and M6 formation. ...