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Pathways of Carbamazepine Bioactivation In Vitro III: The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine
Drug Metab Dispos Pearce et al. 10.1124/dmd.107.019562

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Data Supplement - …under these conditions, covalent binding of 14C3-OHCBZ to mouse liver microsomes in incubations containing NADPH was 5.32 ± 0.19 (in the absence of GSH), 0.91 ± 0.23 (with 1 mM GSH), and 0.38 ± 0.10 (with 4 mM GSH) pmol/pmol P450/30 min, respectively, and appeared to be concentrated in a single band with a molecular weight of ~55 kDa. An image of the full gel is included as supplementary information...

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