Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes
Drug Metab Dispos Bae et al.
36: 1679
Data Supplement
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Data Supplement
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Three P450 isoforms (CYP1A2, CYP2C8, and CYP2C9)
appeared to be associated with sibutramine metabolite formation (Table 2), although they
also showed some correlation with bupropion hydroxylation, CYP2B6, (Fig. 1 in
supplemental material).