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Drug Metabolism and Disposition Fast Forward
First published on July 30, 2007; DOI: 10.1124/dmd.107.017079

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Received for publication June 11, 2007.
Revised July 27, 2007.
Accepted for publication July 30, 2007.

The development of drug metabolism research as expressed in the publications of ASPET Part 1-1909-1958

Patrick Murphy 1*

1 Butler University

* Address correspondence to: E-mail: pjmurphy12{at}aol.com

Abstract

This is the first of three articles covering the development of drug metabolism research in the US during the first 100 years of ASPET. Prior to 1909 the majority of drug metabolism research was performed in Europe. The period from 1909-1958 saw extensive development of the methods required for modern metabolism studies. Examples of trends and specific discoveries are drawn from the archives of ASPET publications.


Key words: analytical pharmacology/toxicology, antibiotics, cytochrome P450, drug disposition, human pharmacokinetics, metabolite identification, phase II drug metabolism


This article has been cited by other articles:


Home page
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P. J. Murphy
The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959-1983
Drug Metab. Dispos., June 1, 2008; 36(6): 981 - 985.
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