Abstract
A liver polyribosomal extract was prepared by high-salt treatment from 3-MC- or BNF-treated rats and was compared with a similarly prepared extract from control liver with respect to the ability to stimulate poly U-directed 14C-phenylalanine incorporation in a cell-free system from liver. The results demonstrated a several-fold stimulation by both extracts from 3-MC- and BNF-treated animals. It was shown that neither amino acid activation nor elongation was affected by such treatment. The ribosomal high-salt extract was separated into M1 and M3 + M2 fractions. The stimulatory effect was associated with the latter. Implications of a possible role of these high-salt factors in enzyme induction are discussed.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics
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