Abstract
A simple integrated method for the calculation of elimination rate constants of a drug and its derived metabolite has been developed. This method is based on the statistical moment theory and requires only simple calculations of the area under the curve and area under the moment curve of the parent drug and its derived metabolite. The application to a drug following a one-compartmental model is theoretically well justified and this method may also be applicable to drugs following higher kinetic models under certain conditions. The application of this method to several experimental cases is also presented.
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.