Abstract
A gas chromatographic analysis to demonstrate the presence of dihydrodigoxin in urine from patients receiving maintenance doses of digoxin has been employed. Dihydrodigoxin, a relatively inactive metabolite of digoxin, was detected in 48 of 50 samples of urine from 50 human subjects. Dihydrodigoxin was, on the average, 13% of the glycosides in the methylene chloride extract of urine (SD ± 9%). Clinical implications of this study are discussed.
Footnotes
- Received October 8, 1973.
- Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.