Abstract
Pretreatment of rats with dibenamine ·HCl (25 mg/kg sc 48 and 24 hr before death) decreased the activity of cytochrome P-450-dependent enzymes in hepatic microsomes as judged by the in vitro N-demethylation of ethylmorphine and dimethylnitrosamine and covalent binding of 14CCI4 and 14C-dimethylnitrosamine. The decrease in enzymatic activity is probably not due solely to a decrease in the amount of cytochrome P-450. Dibenamine pretreatment may protect rats from the hepatotoxicity of CCl4 or dimethylnitrosamine by reducing the formation of active metabolites by microsomal enzymes.
Footnotes
- Received February 18, 1974.
- Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics
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