Abstract
Specific and sensitive assay methods have been developed for propoxyphene and its principal metabolite, norpropoxyphene. The methods involve the use of propoxyphene-d7 and norpropoxyphene-d3 as internal standards and the combined gas chromatograph-mass spectrometer as a detector. The plasma levels of propoxyphene and norpropoxyphene were determined in the rat and dog after a single oral dose of 20 mg of propoxyphene per kg. Of the two species studied, the dog appeared to be more nearly like the human. In dog, levels of metabolite were considerably greater and more persistent than those of parent drug. Multiple-dose studies in dogs indicate that propoxyphene may stimulate its own absorption or metabolism in this species.
Footnotes
- Received June 28, 1974.
- Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.