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Abstract

N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.

B Clement and F Jung
Drug Metabolism and Disposition May 1994, 22 (3) 486-497;

Article Information

vol. 22 no. 3 486-497
PubMed 
8070328
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online May 1, 1994.

Author Information

  1. B Clement and
  2. F Jung
  1. Pharmazeutisches Institut, Christian Albrechts-Universität, Kiel, Germany.

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    Abstract

    N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.

    B Clement and F Jung
    Drug Metabolism and Disposition May 1, 1994, 22 (3) 486-497;
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