Abstract
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology ’98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.
Footnotes
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Send reprint requests to: Edward T. Morgan, Ph.D., Department of Pharmacology, Emory University, Atlanta, GA 30322. e-mail:etmorga{at}emory.edu
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This work was supported by grants GM46897 (E.T.M.), GM53093 (E.T.M.) T32DK07298 (H.I.) GM36590 (R.H.T.) GM32281 (C.J.O.) and Center Grant ES07033 (C.J.O.) from the National Institutes of Health. M.B.S. was supported by a Predoctoral fellowship from the Howard Hughes Medical Institute. C.J.O. is a Burroughs Wellcome Toxicology Scholar.
- Abbreviations used are::
- AdCre
- recombinant adenovirus containing the Cre gene
- Ah
- aryl hydrocarbon
- ARNT
- Ah receptor nuclear translocator
- C/EBP
- CAAT enhancer-binding protein
- Cre
- Cre recombinase
- EMSA
- electrophoretic mobility shift assay
- HNF
- hepatocyte nuclear factor
- IL
- interleukin
- LPS
- bacterial lipopolysaccharide
- NF
- nuclear factor
- NF-1
- nuclear factor 1
- P450
- cytochrome P450
- NOS2
- inducible nitric oxide synthase
- PB
- phenobarbital
- PBRU
- phenobarbital responsive unit
- PKA
- cAMP-activated protein kinase
- PKC
- protein kinase C
- PP
- protein phosphatase
- TCDD
- 2,3,7,8-tetrachlorodibenzo-p-dioxin
- TPA
- tetradecanoyl phorbol acetate
- UDP
- uridine diphosphate
- UGT
- UDPglucuronosyltransferase
- The American Society for Pharmacology and Experimental Therapeutics
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In this issue
Physiological and Pathophysiological Regulation of Cytochrome P450
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- Article
- Abstract
- Mechanisms of P450 Regulation by Inflammation, Cytokines, and Growth Factors (E.T.M., M.B.S., H.I.)
- Conditional Gene Disruption for the Study of Transcription Factors and Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes (F.J.G., Y.-H.L.)
- The Role of Signal Transduction and Ah Receptor–Mediated Transcriptional Activation of the CYP1A1 Gene (R.H.T., S.O., T.V., Y.-H.C.)
- Signaling and Receptor Pathways Modulating Gene Induction by Phenobarbital (J.S.S., C.J.O.)
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