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Research ArticleArticle

Physiological and Pathophysiological Regulation of Cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying-Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue-Hwa Chen, Jaspreet S. Sidhu and Curtis J. Omiecinski
Drug Metabolism and Disposition December 1998, 26 (12) 1232-1240;
Edward T. Morgan
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Marion B. Sewer
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Heinrich Iber
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Frank J. Gonzalez
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Ying-Hue Lee
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Robert H. Tukey
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Steve Okino
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Tien Vu
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Yue-Hwa Chen
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Jaspreet S. Sidhu
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Curtis J. Omiecinski
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Abstract

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology ’98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

Footnotes

  • Send reprint requests to: Edward T. Morgan, Ph.D., Department of Pharmacology, Emory University, Atlanta, GA 30322. e-mail:etmorga{at}emory.edu

  • This work was supported by grants GM46897 (E.T.M.), GM53093 (E.T.M.) T32DK07298 (H.I.) GM36590 (R.H.T.) GM32281 (C.J.O.) and Center Grant ES07033 (C.J.O.) from the National Institutes of Health. M.B.S. was supported by a Predoctoral fellowship from the Howard Hughes Medical Institute. C.J.O. is a Burroughs Wellcome Toxicology Scholar.

  • Abbreviations used are::
    AdCre
    recombinant adenovirus containing the Cre gene
    Ah
    aryl hydrocarbon
    ARNT
    Ah receptor nuclear translocator
    C/EBP
    CAAT enhancer-binding protein
    Cre
    Cre recombinase
    EMSA
    electrophoretic mobility shift assay
    HNF
    hepatocyte nuclear factor
    IL
    interleukin
    LPS
    bacterial lipopolysaccharide
    NF
    nuclear factor
    NF-1
    nuclear factor 1
    P450
    cytochrome P450
    NOS2
    inducible nitric oxide synthase
    PB
    phenobarbital
    PBRU
    phenobarbital responsive unit
    PKA
    cAMP-activated protein kinase
    PKC
    protein kinase C
    PP
    protein phosphatase
    TCDD
    2,3,7,8-tetrachlorodibenzo-p-dioxin
    TPA
    tetradecanoyl phorbol acetate
    UDP
    uridine diphosphate
    UGT
    UDPglucuronosyltransferase
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition
Vol. 26, Issue 12
1 Dec 1998
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Research ArticleArticle

Physiological and Pathophysiological Regulation of Cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying-Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue-Hwa Chen, Jaspreet S. Sidhu and Curtis J. Omiecinski
Drug Metabolism and Disposition December 1, 1998, 26 (12) 1232-1240;

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Research ArticleArticle

Physiological and Pathophysiological Regulation of Cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying-Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue-Hwa Chen, Jaspreet S. Sidhu and Curtis J. Omiecinski
Drug Metabolism and Disposition December 1, 1998, 26 (12) 1232-1240;
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  • Article
    • Abstract
    • Mechanisms of P450 Regulation by Inflammation, Cytokines, and Growth Factors (E.T.M., M.B.S., H.I.)
    • Conditional Gene Disruption for the Study of Transcription Factors and Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes (F.J.G., Y.-H.L.)
    • The Role of Signal Transduction and Ah Receptor–Mediated Transcriptional Activation of the CYP1A1 Gene (R.H.T., S.O., T.V., Y.-H.C.)
    • Signaling and Receptor Pathways Modulating Gene Induction by Phenobarbital (J.S.S., C.J.O.)
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