Abstract
Models describing the plasma concentration-time curves of generated metabolite after iv and oral drug administration are presented. Utilizing numerical inverse Laplace transformation, the method can readily be used for parameter estimation and model simulation in conjunction with appropriate curve-fitting software. The approach is not limited to compartment modeling and can be applied to any linear pharmacokinetic system exhibiting hepatic and renal elimination of the parent drug. The model is formulated for single and multiple dosing of the precursor, including bolus doses and/or infusions for iv administration and sustained-release dosage forms for oral administration.
Footnotes
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Send reprint requests to: Dr. Michael Weiss, Section of Pharmacokinetics, Department of Pharmacology, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany.
- Abbreviations used are::
- AUC
- area under the curve
- C(t)
- concentration-time curve
- MAT
- mean absorption time
- MTT
- mean transit time
- Received November 17, 1997.
- Accepted February 20, 1998.
- The American Society for Pharmacology and Experimental Therapeutics
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