Abstract
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics presented at the joint meeting of the American Society for Biochemistry and Molecular Biology and the American Society for Pharmacology and Experimental Therapeutics, June 4–8, Boston, Massachusetts. The presentations focused on the pharmacogenetics of the NAT1 and NAT2 arylamineN-acetyltransferases, including developmental regulation, structure-function relationships, and their possible role in susceptibility to breast, colon, and pancreatic cancers. The symposium honored Wendell W. Weber for over 35 years of leadership and scientific advancement in pharmacogenetics and was highlighted by his overview of the historical development of the field.
Footnotes
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Send reprint requests to: David W. Hein, Department of Pharmacology and Toxicology, University of Louisville Helath Science Center, Louisville, KY 40292. E-mail: d.hein{at}louisville.edu
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This work was supported in part by Grants CA-34627 (D.W.H.), ES10047, ES09812, and Arizona Disease Control Research Commission (C.A.M).
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↵2 N-Acetyltransferase proteins and genes are printed in regular type (NAT) and italics (NAT), respectively.
- Abbreviations used are::
- NAT
- N-acetyltransferase
- NAT1
- N-acetyltransferase 1
- NAT2
- N-acetyltransferase 2
- 4-ABP
- 4-aminobiphenyl
- GD
- gestational day
- ND
- neonatal day
- PABA
- p-aminobenzoic acid
- PABA-Glu
- p-aminobenzoyl glutamate
- PAS
- p-aminosalicylic acid
- SMZ
- sulfamethazine
- AFMU/1X
- 5-acetylamino-6-formylamino-3-methyluracil/1-methylxanthine
- OR
- odds ratio
- CI
- confidence interval
- Received July 17, 2000.
- Accepted September 11, 2000.
- The American Society for Pharmacology and Experimental Therapeutics
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