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Research ArticleArticle

Decreases in Phenytoin Hydroxylation Activities Catalyzed by Liver Microsomal Cytochrome P450 Enzymes in Phenytoin-Treated Rats

Hiroshi Yamazaki, Tomoko Komatsu, Kei Takemoto, Mayuko Saeki, Yoshinori Minami, Yasuro Kawaguchi, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition April 2001, 29 (4) 427-434;
Hiroshi Yamazaki
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Tomoko Komatsu
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Kei Takemoto
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Mayuko Saeki
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Yoshinori Minami
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Yasuro Kawaguchi
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Noriaki Shimada
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Miki Nakajima
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Tsuyoshi Yokoi
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Article Information

vol. 29 no. 4 427-434
PubMed 
11259327

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 6, 2000
  • Accepted January 4, 2001
  • Published online April 1, 2001.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hiroshi Yamazaki1,
  2. Tomoko Komatsu1,
  3. Kei Takemoto1,
  4. Mayuko Saeki2,
  5. Yoshinori Minami2,
  6. Yasuro Kawaguchi2,
  7. Noriaki Shimada3,
  8. Miki Nakajima1 and
  9. Tsuyoshi Yokoi1
  1. 1Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (H.Y., T.K., K.T., M.N., T.Y.); 2Taiho Pharmaceutical Company, Tokushima, Japan (M.S., Y.M., Y.K.); and 3Daiichi Pure Chemicals, Ibaraki, Japan (N.S.)
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    Drug Metabolism and Disposition: 29 (4)
    Drug Metabolism and Disposition
    Vol. 29, Issue 4
    1 Apr 2001
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    Research ArticleArticle

    Decreases in Phenytoin Hydroxylation Activities Catalyzed by Liver Microsomal Cytochrome P450 Enzymes in Phenytoin-Treated Rats

    Hiroshi Yamazaki, Tomoko Komatsu, Kei Takemoto, Mayuko Saeki, Yoshinori Minami, Yasuro Kawaguchi, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 1, 2001, 29 (4) 427-434;

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    Research ArticleArticle

    Decreases in Phenytoin Hydroxylation Activities Catalyzed by Liver Microsomal Cytochrome P450 Enzymes in Phenytoin-Treated Rats

    Hiroshi Yamazaki, Tomoko Komatsu, Kei Takemoto, Mayuko Saeki, Yoshinori Minami, Yasuro Kawaguchi, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 1, 2001, 29 (4) 427-434;
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