Index by author
September 01, 2006; Volume 34,Issue 9
A
Akita, Hidetaka
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Ando, Yosuke
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Arakawa, Shingo
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Atkins, William M.
- You have accessA Theoretical Validation of the Substrate Depletion Approach to Determining Kinetic ParametersAbhinav Nath and William M. AtkinsDrug Metabolism and Disposition September 2006, 34 (9) 1433-1435; DOI: https://doi.org/10.1124/dmd.106.010777
B
Balani, Suresh K.
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Beattie, Iain G.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Becker, Stacey L.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Bernard, Olivier
- You have accessInfluence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic AcidOlivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal GuillemetteDrug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
Bernstein, Michael A.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Bi, Yi-an
- You have accessUse of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary TransportYi-an Bi, Diana Kazolias and David B. DuignanDrug Metabolism and Disposition September 2006, 34 (9) 1658-1665; DOI: https://doi.org/10.1124/dmd.105.009118
Boström, Emma
- You have accessIn Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/PharmacodynamicsEmma Boström, Ulrika S. H. Simonsson and Margareta Hammarlund-UdenaesDrug Metabolism and Disposition September 2006, 34 (9) 1624-1631; DOI: https://doi.org/10.1124/dmd.106.009746
C
Callegari, Ernesto
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Carr, Brian
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Castell, José V.
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Chan, Eli
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Chen, Chi
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Chen, Cuiping
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Chen, Jie
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Chen, Shuqing
- You have accessGenetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han PopulationYakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su ZengDrug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
Chen, Xi
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Chen, Xianghai
- You have accessP-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrileShanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy PangDrug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
Chen, Xiao
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Chen, Yakun
- You have accessGenetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han PopulationYakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su ZengDrug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
Cho, Taehyeon M.
- You have accessInhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other ChemicalsKhawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest HodgsonDrug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
Cianfrogna, Julie
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
D
Dean, Dennis
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Donato, M. Teresa
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Doran, Angela C.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Doran, Shawn D.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Drescher, Anja
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Duan, Wei
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Duignan, David B.
- You have accessUse of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary TransportYi-an Bi, Diana Kazolias and David B. DuignanDrug Metabolism and Disposition September 2006, 34 (9) 1658-1665; DOI: https://doi.org/10.1124/dmd.105.009118
Dunbar, Anwar Y.
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
F
Fate, Gwendolyn D.
- You have accessUsing a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange RiskChristopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. FateDrug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
Finel, Moshe
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
Franklin, Ronald B.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Fujimoto, Kazunori
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
G
Gallegos, Richard
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Gan, Liang-Shang
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Gibbs, John P.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
- You have accessMinimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 MetabolismJohn P. Gibbs, Ruth Hyland and Kuresh YoudimDrug Metabolism and Disposition September 2006, 34 (9) 1516-1522; DOI: https://doi.org/10.1124/dmd.105.008714
Gómez-Lechón, M. José
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Gonzalez, Frank J.
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Guillemette, Chantal
- You have accessInfluence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic AcidOlivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal GuillemetteDrug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
Gunduz, Mithat
- You have accessUsing a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange RiskChristopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. FateDrug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
H
Haberl, Michael
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Hammarlund-Udenaes, Margareta
- You have accessIn Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/PharmacodynamicsEmma Boström, Ulrika S. H. Simonsson and Margareta Hammarlund-UdenaesDrug Metabolism and Disposition September 2006, 34 (9) 1624-1631; DOI: https://doi.org/10.1124/dmd.106.009746
Hara, Ayako
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Hayashi, Hisamitsu
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
He, Ming
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Heining, Peter
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Hodgson, Ernest
- You have accessInhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other ChemicalsKhawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest HodgsonDrug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
Hofmann, Alan F.
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Hollenberg, Paul F.
- You have accessMechanism of Inactivation of Human Cytochrome P450 2B6 by PhencyclidineMonica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. WienkersDrug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
Hosea, Natilie
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Hu, Ze-Ping
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Huang, Min
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Hutson, Janine R.
- You have accessRegulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-MethylcholanthreneChunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. RiddickDrug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
Hyland, Ruth
- You have accessMinimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 MetabolismJohn P. Gibbs, Ruth Hyland and Kuresh YoudimDrug Metabolism and Disposition September 2006, 34 (9) 1516-1522; DOI: https://doi.org/10.1124/dmd.105.008714
I
Idle, Jeffrey R.
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Irth, H.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
Iwabuchi, Haruo
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
J
Jenkins, Gary J.
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
Jianmongkol, Suree
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
Jiménez, Nuria
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Jones, Allen N.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Journault, Kim
- You have accessInfluence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic AcidOlivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal GuillemetteDrug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
Jung, Diana
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Jushchyshyn, Monica I.
- You have accessMechanism of Inactivation of Human Cytochrome P450 2B6 by PhencyclidineMonica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. WienkersDrug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
Jusko, William J.
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
K
Kazolias, Diana
- You have accessUse of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary TransportYi-an Bi, Diana Kazolias and David B. DuignanDrug Metabolism and Disposition September 2006, 34 (9) 1658-1665; DOI: https://doi.org/10.1124/dmd.105.009118
Keil, Andrea
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Kerb, Reinhold
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Kessler, Fay K.
- You have accessCharacterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic AcidKristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. RitterDrug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
Kochansky, Christopher J.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Kool, J.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
Kostiainen, Risto
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
Krausz, Kristopher W.
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Kullak-Ublick, Gerd A.
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Kuo, Yuhsin
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
L
Lahoz, Agustín
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Lang, Thomas
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Lasseter, Kenneth
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Lau, Miranda
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
Lee, Anna M.
- You have accessIn Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine TreatmentAnna M. Lee, Jiang Yue and Rachel F. TyndaleDrug Metabolism and Disposition September 2006, 34 (9) 1508-1515; DOI: https://doi.org/10.1124/dmd.106.010363
Lee, Chunja
- You have accessRegulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-MethylcholanthreneChunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. RiddickDrug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
Lee, Kuo-Hsiung
- You have accessStructural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and PlasmaZhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. SmithDrug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
Lewis, Richard J.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Li, Chunze
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Li, Hongshan
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Li, Ping
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Li, Xin
- You have accessGenetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han PopulationYakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su ZengDrug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
Lin, Jiunn H.
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Liu, Jianhua
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Liu, Shanjun
- You have accessP-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrileShanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy PangDrug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
Liu, Xingrong
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Lowe, Ezra R.
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
Lowe, Philip
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Lu, Bing
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Lu, Chuang
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Luukkanen, Leena
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
M
Manabe, Sunao
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Martin, Craig A.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Martin, David E.
- You have accessStructural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and PlasmaZhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. SmithDrug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
Martin, Iain J.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
McPhail, Kerry L.
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Meno-Tetang, Guy M. L.
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Miida, Hiroaki
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Miles, Kristini K.
- You have accessCharacterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic AcidKristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. RitterDrug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
Mir, José
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Mis, Suzette
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Mita, Sachiko
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Miwa, Gerald T.
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Mornhinweg, Esther
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
N
Nakatsuka, Mikiya
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
Nath, Abhinav
- You have accessA Theoretical Validation of the Substrate Depletion Approach to Determining Kinetic ParametersAbhinav Nath and William M. AtkinsDrug Metabolism and Disposition September 2006, 34 (9) 1433-1435; DOI: https://doi.org/10.1124/dmd.106.010777
Nelson, Frederick R.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Niessen, W. M. A.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
O
Onuki, Reiko
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Osawa, Yoichi
- You have accessTetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in VivoAnwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau and Yoichi OsawaDrug Metabolism and Disposition September 2006, 34 (9) 1448-1456; DOI: https://doi.org/10.1124/dmd.106.009951
P
Pang, K. Sandy
- You have accessP-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrileShanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy PangDrug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
Pérez, Gabriela
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Perlík, František
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Perusse, Louis
- You have accessInfluence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic AcidOlivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal GuillemetteDrug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
Prueksaritanont, Thomayant
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Pyszczynski, Nancy
- You have accessPhysiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous DosesGuy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe and William J. JuskoDrug Metabolism and Disposition September 2006, 34 (9) 1480-1487; DOI: https://doi.org/10.1124/dmd.105.009001
Q
Qiu, Yue
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Qvisen, Saana
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
R
Richards, Karen
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Riddick, David S.
- You have accessRegulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-MethylcholanthreneChunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. RiddickDrug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
Riley, Robert J.
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Rippley, Ronda K.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Ritter, Joseph K.
- You have accessCharacterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic AcidKristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. RitterDrug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
Rose, Randy L.
- You have accessInhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other ChemicalsKhawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest HodgsonDrug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
S
Schlagenhaufer, Robert
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Schwartz, Jules
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Serralta, Alfonso
- You have accessPotential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver GraftsM. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell and M. José Gómez-LechónDrug Metabolism and Disposition September 2006, 34 (9) 1556-1562; DOI: https://doi.org/10.1124/dmd.106.009670
Shaffer, Christopher L.
- You have accessUsing a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange RiskChristopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. FateDrug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
Sheu, Fwu-Shan
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Shibaya, Yukari
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Simonsson, Ulrika S. H.
- You have accessIn Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/PharmacodynamicsEmma Boström, Ulrika S. H. Simonsson and Margareta Hammarlund-UdenaesDrug Metabolism and Disposition September 2006, 34 (9) 1624-1631; DOI: https://doi.org/10.1124/dmd.106.009746
Slanař, Ondřej
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Slavík, Josef
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Smith, Bill J.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
Smith, Philip C.
- You have accessStructural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and PlasmaZhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. SmithDrug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
- You have accessCharacterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic AcidKristini K. Miles, Fay K. Kessler, Philip C. Smith and Joseph K. RitterDrug Metabolism and Disposition September 2006, 34 (9) 1632-1639; DOI: https://doi.org/10.1124/dmd.106.010140
Song, Hengchang
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Springthorpe, Brian
- You have accessWhich Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in VivoIain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley and Brian SpringthorpeDrug Metabolism and Disposition September 2006, 34 (9) 1502-1507; DOI: https://doi.org/10.1124/dmd.106.009282
Sten, Taina
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
Stern, Stephan T.
- You have accessStructural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and PlasmaZhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. SmithDrug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
Stieger, Bruno
- You have accessGenetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick and Reinhold KerbDrug Metabolism and Disposition September 2006, 34 (9) 1582-1599; DOI: https://doi.org/10.1124/dmd.105.008854
Strong-Basalyga, Kristie
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Sugiyama, Yuichi
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Suzuki, Hiroshi
- You have accessInhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing DrugsSachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann and Yuichi SugiyamaDrug Metabolism and Disposition September 2006, 34 (9) 1575-1581; DOI: https://doi.org/10.1124/dmd.105.008748
Szewc, Mark A.
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
T
Takasaki, Wataru
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Tam, Debbie
- You have accessP-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrileShanjun Liu, Debbie Tam, Xianghai Chen and K. Sandy PangDrug Metabolism and Disposition September 2006, 34 (9) 1468-1479; DOI: https://doi.org/10.1124/dmd.105.008227
Tang, Cuyue
- You have accessIn Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction StudiesThomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr and Jiunn H. LinDrug Metabolism and Disposition September 2006, 34 (9) 1546-1555; DOI: https://doi.org/10.1124/dmd.106.009878
Thornburgh, Bruce A.
- You have accessUsing a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange RiskChristopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh and Gwendolyn D. FateDrug Metabolism and Disposition September 2006, 34 (9) 1615-1623; DOI: https://doi.org/10.1124/dmd.106.010934
Tojcic, Jelena
- You have accessInfluence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic AcidOlivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse and Chantal GuillemetteDrug Metabolism and Disposition September 2006, 34 (9) 1539-1545; DOI: https://doi.org/10.1124/dmd.106.010553
Tyndale, Rachel F.
- You have accessIn Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine TreatmentAnna M. Lee, Jiang Yue and Rachel F. TyndaleDrug Metabolism and Disposition September 2006, 34 (9) 1508-1515; DOI: https://doi.org/10.1124/dmd.106.010363
Tzau, Vivien Kok-Fung
- You have accessRegulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-MethylcholanthreneChunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau and David S. RiddickDrug Metabolism and Disposition September 2006, 34 (9) 1530-1538; DOI: https://doi.org/10.1124/dmd.106.009936
U
Uchiyama, Minoru
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Usmani, Khawja A.
- You have accessInhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other ChemicalsKhawja A. Usmani, Taehyeon M. Cho, Randy L. Rose and Ernest HodgsonDrug Metabolism and Disposition September 2006, 34 (9) 1606-1614; DOI: https://doi.org/10.1124/dmd.106.010439
Uttamsingh, Vinita
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Uutela, Päivi
- You have accessProminent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen and Moshe FinelDrug Metabolism and Disposition September 2006, 34 (9) 1488-1494; DOI: https://doi.org/10.1124/dmd.106.010371
V
Van Deusen, Jeffrey
- You have accessEvaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free ConcentrationXingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van DeusenDrug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
van Elswijk, D. E.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
van Liempd, S. M.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
Vermeulen, N. P. E.
- You have accessOn-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor ModulatorsS. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth and N. P. E. VermeulenDrug Metabolism and Disposition September 2006, 34 (9) 1640-1649; DOI: https://doi.org/10.1124/dmd.106.010355
Vincent, Stella H.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
W
Wagner, John
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Wahlstrom, Jan L.
- You have accessMechanism of Inactivation of Human Cytochrome P450 2B6 by PhencyclidineMonica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. WienkersDrug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
Wallace, Michael A.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Wang, Xiewei
- You have accessGenetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han PopulationYakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su ZengDrug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
Wen, Zhiming
- You have accessStructural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3′,3′-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and PlasmaZhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee and Philip C. SmithDrug Metabolism and Disposition September 2006, 34 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.106.009233
Wienkers, Larry C.
- You have accessMechanism of Inactivation of Human Cytochrome P450 2B6 by PhencyclidineMonica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg and Larry C. WienkersDrug Metabolism and Disposition September 2006, 34 (9) 1523-1529; DOI: https://doi.org/10.1124/dmd.106.010579
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Xia, Cindy Q.
- You have accessComparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in HepatocytesChuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani and Liang-Shang GanDrug Metabolism and Disposition September 2006, 34 (9) 1600-1605; DOI: https://doi.org/10.1124/dmd.106.010793
Y
Yamoto, Takashi
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Yan, Kerri X.
- You have accessAbsorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in HumansChristopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin and John WagnerDrug Metabolism and Disposition September 2006, 34 (9) 1457-1461; DOI: https://doi.org/10.1124/dmd.106.010231
Yang, Xiao-Xia
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
Yasumo, Hiroaki
- You have accessCharacterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-NitrobenzeneKazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe and Takashi YamotoDrug Metabolism and Disposition September 2006, 34 (9) 1495-1501; DOI: https://doi.org/10.1124/dmd.106.010009
Youdim, Kuresh
- You have accessMinimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 MetabolismJohn P. Gibbs, Ruth Hyland and Kuresh YoudimDrug Metabolism and Disposition September 2006, 34 (9) 1516-1522; DOI: https://doi.org/10.1124/dmd.105.008714
Yue, Jiang
- You have accessIn Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine TreatmentAnna M. Lee, Jiang Yue and Rachel F. TyndaleDrug Metabolism and Disposition September 2006, 34 (9) 1508-1515; DOI: https://doi.org/10.1124/dmd.106.010363
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Zabriskie, T. Mark
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Zeng, Su
- You have accessGenetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han PopulationYakun Chen, Shuqing Chen, Xin Li, Xiewei Wang and Su ZengDrug Metabolism and Disposition September 2006, 34 (9) 1462-1467; DOI: https://doi.org/10.1124/dmd.106.009761
Zhen, Yueying
- You have access3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic RatioYueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez and Jeffrey R. IdleDrug Metabolism and Disposition September 2006, 34 (9) 1563-1574; DOI: https://doi.org/10.1124/dmd.105.008920
Zhou, Shu-Feng
- You have accessSmall Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 GeneJie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen and Shu-Feng ZhouDrug Metabolism and Disposition September 2006, 34 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.106.009837
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