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Research ArticleArticle

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf and Gordon C. K. Roberts
Drug Metabolism and Disposition October 2008, 36 (10) 2136-2144; DOI: https://doi.org/10.1124/dmd.108.021733
Yury Kapelyukh
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Mark J. I. Paine
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Jean-Didier Maréchal
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Michael J. Sutcliffe
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C. Roland Wolf
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Gordon C. K. Roberts
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Article Information

vol. 36 no. 10 2136-2144
DOI 
https://doi.org/10.1124/dmd.108.021733
PubMed 
18645035

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 4, 2008
  • Accepted July 17, 2008
  • Published online September 22, 2008.

Article Versions

  • Earlier version (July 21, 2008 - 12:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yury Kapelyukh1,
  2. Mark J. I. Paine2,
  3. Jean-Didier Maréchal3,
  4. Michael J. Sutcliffe4,
  5. C. Roland Wolf and
  6. Gordon C. K. Roberts
  1. Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical, School, Dundee, United Kingdom (Y.K., M.J.I.P., C.R.W.); CXR Biosciences, James Lindsay Place, Dundee Technopole, Dundee, United Kingdom (C.R.W.); Departments of Biochemistry (G.C.K.R.) and Chemistry (J.-D.M., M.J.S.), University of Leicester, Leicester, United Kingdom
  1. Address correspondence to:
    Gordon C. K. Roberts, Department of Biochemistry, Henry Wellcome Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, UK. E-mail: gcr{at}le.ac.uk
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Drug Metabolism and Disposition: 36 (10)
Drug Metabolism and Disposition
Vol. 36, Issue 10
1 Oct 2008
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Research ArticleArticle

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf and Gordon C. K. Roberts
Drug Metabolism and Disposition October 1, 2008, 36 (10) 2136-2144; DOI: https://doi.org/10.1124/dmd.108.021733

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Research ArticleArticle

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf and Gordon C. K. Roberts
Drug Metabolism and Disposition October 1, 2008, 36 (10) 2136-2144; DOI: https://doi.org/10.1124/dmd.108.021733
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