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Drug Metabolism & Disposition

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Table of Contents

June 01, 2009; Volume 37,Issue 6

Short Communications

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    Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Pramod Upadhyaya, Bruce R. Lindgren and Stephen S. Hecht
    Drug Metabolism and Disposition June 2009, 37 (6) 1147-1151; DOI: https://doi.org/10.1124/dmd.109.027078
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    The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxyethylamphetamine and Its Single Enantiomers
    Markus R. Meyer, Frank T. Peters and Hans H. Maurer
    Drug Metabolism and Disposition June 2009, 37 (6) 1152-1156; DOI: https://doi.org/10.1124/dmd.108.026203

Articles

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    Fenofibrate Metabolism in the Cynomolgus Monkey using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics
    Aiming Liu, Andrew D. Patterson, Zongtao Yang, Xinying Zhang, Wei Liu, Fayang Qiu, He Sun, Kristopher W. Krausz, Jeffrey R. Idle, Frank J. Gonzalez and Renke Dai
    Drug Metabolism and Disposition June 2009, 37 (6) 1157-1163; DOI: https://doi.org/10.1124/dmd.108.025817
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    Pharmacokinetics of the Dipeptidyl Peptidase 4 Inhibitor Saxagliptin in Rats, Dogs, and Monkeys and Clinical Projections
    Aberra Fura, Ashish Khanna, Viral Vyas, Barry Koplowitz, Shu-Ying Chang, Christian Caporuscio, David W. Boulton, Lisa J. Christopher, Kristina D. Chadwick, Lawrence G. Hamann, W. Griffith Humphreys and Mark Kirby
    Drug Metabolism and Disposition June 2009, 37 (6) 1164-1171; DOI: https://doi.org/10.1124/dmd.108.026088
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    Long-Lasting Inhibition of the Transporter-Mediated Hepatic Uptake of Sulfobromophthalein by Cyclosporin A in Rats
    Yoshihisa Shitara, Yoshiko Nagamatsu, Satomi Wada, Yuichi Sugiyama and Toshiharu Horie
    Drug Metabolism and Disposition June 2009, 37 (6) 1172-1178; DOI: https://doi.org/10.1124/dmd.108.025544
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    Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat
    Walter Meinl, Silke Sczesny, Regina Brigelius-Flohé, Michael Blaut and Hansruedi Glatt
    Drug Metabolism and Disposition June 2009, 37 (6) 1179-1186; DOI: https://doi.org/10.1124/dmd.108.025916
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    Oxidized Metabolites of Oltipraz Exert Cytoprotective Effects against Arachidonic Acid through AMP-Activated Protein Kinase-Dependent Cellular Antioxidant Effect and Mitochondrial Protection
    Young Nam Kwon, Sang Mi Shin, Il Je Cho and Sang Geon Kim
    Drug Metabolism and Disposition June 2009, 37 (6) 1187-1197; DOI: https://doi.org/10.1124/dmd.108.025908
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    Interactions of Olomoucine II with Human Liver Microsomal Cytochromes P450
    Michal Siller, Pavel Anzenbacher, Eva Anzenbacherova, Karel Dolezal, Igor Popa and Miroslav Strnad
    Drug Metabolism and Disposition June 2009, 37 (6) 1198-1202; DOI: https://doi.org/10.1124/dmd.108.025502
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    Novobiocin Is a Potent Inhibitor for Human Organic Anion Transporters
    Peng Duan and Guofeng You
    Drug Metabolism and Disposition June 2009, 37 (6) 1203-1210; DOI: https://doi.org/10.1124/dmd.109.026880
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    Protein Electrophile-Binding Motifs: Lysine-Rich Proteins Are Preferential Targets of Quinones
    Matthew T. Labenski, Ashley A. Fisher, Herng-Hsiang Lo, Terrence J. Monks and Serrine S. Lau
    Drug Metabolism and Disposition June 2009, 37 (6) 1211-1218; DOI: https://doi.org/10.1124/dmd.108.026211
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    Metabolic Disposition of [14C]Bazedoxifene in Healthy Postmenopausal Women
    Appavu Chandrasekaran, William E. McKeand, Pamela Sullivan, William DeMaio, Randall Stoltz and JoAnn Scatina
    Drug Metabolism and Disposition June 2009, 37 (6) 1219-1225; DOI: https://doi.org/10.1124/dmd.108.023861
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    Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System
    Markus Fridén, Frederic Ducrozet, Brian Middleton, Madeleine Antonsson, Ulf Bredberg and Margareta Hammarlund-Udenaes
    Drug Metabolism and Disposition June 2009, 37 (6) 1226-1233; DOI: https://doi.org/10.1124/dmd.108.026377
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    Quantitative Prediction of in Vivo Profiles of CYP3A4 Induction in Humans from in Vitro Results with a Reporter Gene Assay
    Masanari Kozawa, Masashi Honma and Hiroshi Suzuki
    Drug Metabolism and Disposition June 2009, 37 (6) 1234-1241; DOI: https://doi.org/10.1124/dmd.108.025734
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    Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways
    Xiaohai Li, Yuanjun He, Claudia H. Ruiz, Marcel Koenig and Michael D. Cameron
    Drug Metabolism and Disposition June 2009, 37 (6) 1242-1250; DOI: https://doi.org/10.1124/dmd.108.025932
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    Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier
    Rong Zhao, Thomas J. Raub, Geri A. Sawada, Steven C. Kasper, James A. Bacon, Arlene S. Bridges and Gary M. Pollack
    Drug Metabolism and Disposition June 2009, 37 (6) 1251-1258; DOI: https://doi.org/10.1124/dmd.108.025064
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    Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells
    Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser and Robert J. Riley
    Drug Metabolism and Disposition June 2009, 37 (6) 1259-1268; DOI: https://doi.org/10.1124/dmd.109.026526
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    Expression Quantitative Trait Loci Mapping Identifies New Genetic Models of Glutathione S-Transferase Variation
    Kevin R. Hayes, Brandon M. Young and Mathew T. Pletcher
    Drug Metabolism and Disposition June 2009, 37 (6) 1269-1276; DOI: https://doi.org/10.1124/dmd.109.026856
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    Regulation of Expression and Activity of Rat Intestinal Multidrug Resistance-Associated Protein 2 by Cholestatic Estrogens
    Agostina Arias, Silvina S. M. Villanueva, María L. Ruiz, Marcelo G. Luquita, Luis M. Veggi, José M. Pellegrino, Mary Vore, Viviana A. Catania and Aldo D. Mottino
    Drug Metabolism and Disposition June 2009, 37 (6) 1277-1285; DOI: https://doi.org/10.1124/dmd.108.025643
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    In Vitro and in Silico Identification and Characterization of Thiabendazole as a Mechanism-Based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-Drug Interactions
    Roslyn S. Thelingwani, Simbarashe P. Zvada, Hugues Dolgos, Anna-Lena B. Ungell and Collen M. Masimirembwa
    Drug Metabolism and Disposition June 2009, 37 (6) 1286-1294; DOI: https://doi.org/10.1124/dmd.108.024604
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    The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation
    Yvonne S. Lin, Kazuto Yasuda, Mahfoud Assem, Cynthia Cline, Joe Barber, Chia-Wei Li, Vladyslav Kholodovych, Ni Ai, J. Don Chen, William J. Welsh, Sean Ekins and Erin G. Schuetz
    Drug Metabolism and Disposition June 2009, 37 (6) 1295-1304; DOI: https://doi.org/10.1124/dmd.108.025213
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    Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes
    Karen Mathijs, Anne S. Kienhuis, Karen J. J. Brauers, Danyel G. J. Jennen, Agustin Lahoz, Jos C. S. Kleinjans and Joost H. M. van Delft
    Drug Metabolism and Disposition June 2009, 37 (6) 1305-1311; DOI: https://doi.org/10.1124/dmd.108.025775
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    Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser
    Oliver Zolk, Thomas F. Solbach, Jörg König and Martin F. Fromm
    Drug Metabolism and Disposition June 2009, 37 (6) 1312-1318; DOI: https://doi.org/10.1124/dmd.108.023762
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    Key Residues Controlling Binding of Diverse Ligands to Human Cytochrome P450 2A Enzymes
    N. M. DeVore, B. D. Smith, J. L. Wang, G. H. Lushington and E. E. Scott
    Drug Metabolism and Disposition June 2009, 37 (6) 1319-1327; DOI: https://doi.org/10.1124/dmd.109.026765
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    Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection
    Santosh Kumar, Huan Qiu, Numan Oezguen, Holger Herlyn, James R. Halpert and Leszek Wojnowski
    Drug Metabolism and Disposition June 2009, 37 (6) 1328-1333; DOI: https://doi.org/10.1124/dmd.108.024372

Accelerated Communication

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    INTESTINAL PERFUSION WITH MESENTERIC BLOOD SAMPLING IN WILD-TYPE AND KNOCKOUT MICE
    Raf Mols, Joachim Brouwers, Alfred H. Schinkel, Pieter Annaert and Patrick Augustijns
    Drug Metabolism and Disposition June 2009, 37 (6) 1334-1337; DOI: https://doi.org/10.1124/dmd.109.026591
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In this issue

Drug Metabolism and Disposition: 37 (6)
Drug Metabolism and Disposition
Vol. 37, Issue 6
1 Jun 2009
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