Research ArticleArticle
Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists
Tanya Hay, Rhys Jones, Kevin Beaumont and Mark Kemp
Drug Metabolism and Disposition September 2009, 37 (9) 1864-1870; DOI: https://doi.org/10.1124/dmd.109.027888