Research ArticleArticle
Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery
Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
Drug Metabolism and Disposition January 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490
Abdul Mutlib
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Robert Espina
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Karthick Vishwanathan
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Kathlene Babalola
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Zecheng Chen
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Christoph Dehnhardt
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Aranapakam Venkatesan
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Tarek Mansour
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Inder Chaudhary
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
Rasmy Talaat
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
JoAnn Scatina
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Research ArticleArticle
Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery
Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
Drug Metabolism and Disposition January 1, 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490
Research ArticleArticle
Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery
Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
Drug Metabolism and Disposition January 1, 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement