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Research ArticleArticle

Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate

Maria L. H. Vlaming, Anita van Esch, Evita van de Steeg, Zeliha Pala, Els Wagenaar, Olaf van Tellingen and Alfred H. Schinkel
Drug Metabolism and Disposition August 2011, 39 (8) 1338-1344; DOI: https://doi.org/10.1124/dmd.111.038794
Maria L. H. Vlaming
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Anita van Esch
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Evita van de Steeg
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Zeliha Pala
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Els Wagenaar
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Olaf van Tellingen
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Alfred H. Schinkel
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Article Information

vol. 39 no. 8 1338-1344
DOI 
https://doi.org/10.1124/dmd.111.038794
PubMed 
21566011

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 16, 2011
  • Accepted May 12, 2011
  • Published online July 18, 2011.

Article Versions

  • Earlier version (May 12, 2011 - 07:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maria L. H. Vlaming1,
  2. Anita van Esch,
  3. Evita van de Steeg1,
  4. Zeliha Pala,
  5. Els Wagenaar,
  6. Olaf van Tellingen and
  7. Alfred H. Schinkel
  1. Divisions of Molecular Biology (M.L.H.V., A.v.E., E.v.d.S., E.W., A.H.S.) and Clinical Chemistry (O.v.T.), The Netherlands Cancer Institute, Amsterdam, The Netherlands; and Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey (Z.P.)
  1. Address correspondence to:
    Dr. Alfred H. Schinkel, Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. E-mail: a.schinkel{at}nki.nl
  1. A preliminary version of this study was previously presented as follows: Vlaming M (2009) ABC Transporter Compound Knockout Mice: Physiological and Pharmacological Characterization. Ph.D. thesis, University of Amsterdam, Amsterdam, The Netherlands.

  • ↵1 Current affiliation: TNO, Zeist, The Netherlands.

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Drug Metabolism and Disposition: 39 (8)
Drug Metabolism and Disposition
Vol. 39, Issue 8
1 Aug 2011
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Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate
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Research ArticleArticle

Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate

Maria L. H. Vlaming, Anita van Esch, Evita van de Steeg, Zeliha Pala, Els Wagenaar, Olaf van Tellingen and Alfred H. Schinkel
Drug Metabolism and Disposition August 1, 2011, 39 (8) 1338-1344; DOI: https://doi.org/10.1124/dmd.111.038794

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Research ArticleArticle

Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate

Maria L. H. Vlaming, Anita van Esch, Evita van de Steeg, Zeliha Pala, Els Wagenaar, Olaf van Tellingen and Alfred H. Schinkel
Drug Metabolism and Disposition August 1, 2011, 39 (8) 1338-1344; DOI: https://doi.org/10.1124/dmd.111.038794
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