Article Information
- Received February 7, 2011
- Accepted April 27, 2011
- Published online July 18, 2011.
Article Versions
- Earlier version (April 27, 2011 - 07:45).
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Author Information
- Andrew Parkinson,
- Faraz Kazmi,
- David B. Buckley,
- Phyllis Yerino,
- Brandy L. Paris,
- Jeff Holsapple,
- Paul Toren,
- Steve M. Otradovec and
- Brian W. Ogilvie
- Address correspondence to:
Dr. Andrew Parkinson, XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219. E-mail: aparkinson{at}xenotechllc.com
Parts of this work were previously presented at the following meetings: Parkinson A (2009) Metabolism-dependent inhibition (MDI) studies: ten things worth knowing and Paris BL, Kazmi F, Buckley DB, Ogilvie BW, Gipson AE, and Parkinson A (2009) Pitfalls in the design of CYP inhibition studies incorporating a dilution step to examine time-dependent inhibition (TDI) or metabolism-dependent inhibition (MDI). Sixteenth North American Regional ISSX Meeting; 2009 Oct 18–22; Baltimore, MD. International Society for the Study of Xenobiotics, Washington, DC; Buckley DB, Kazmi F, Yerino P, Toren P, Holsapple J, Ogilvie BW, Paris BL, and Parkinson A (2010) Pitfalls in the design of metabolism-dependent CYP inhibition (MDI) experiments with a dilution step: inhibitor depletion by metabolism and/or microsomal binding leads to underestimation of the shifted IC50 value. Ninth International ISSX Meeting; 2010 Sept 4–8; Istanbul, Turkey. International Society for the Study of Xenobiotics, Washington, DC.