Research ArticleArticle
Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics
Hongbo Zhang, Anne-Sisko Patana, Peter I. Mackenzie, Shinichi Ikushiro, Adrian Goldman and Moshe Finel
Drug Metabolism and Disposition October 2012, 40 (10) 1935-1944; DOI: https://doi.org/10.1124/dmd.112.046086
Hongbo Zhang
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
Anne-Sisko Patana
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
Peter I. Mackenzie
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
Shinichi Ikushiro
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
Adrian Goldman
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
Moshe Finel
Centre for Drug Research (H.Z., M.F.) and Division of Pharmaceutical Chemistry (H.Z.), Faculty of Pharmacy, and Institute of Biotechnology (A.-S.P., A.G.), University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia (P.I.M.); and Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan (S.I.)
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ACTIVE, INACTIVE, AND His-TAGGED RECOMBINANT HUMAN UGT
Hongbo Zhang, Anne-Sisko Patana, Peter I. Mackenzie, Shinichi Ikushiro, Adrian Goldman and Moshe Finel
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1935-1944; DOI: https://doi.org/10.1124/dmd.112.046086
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