Research ArticleArticle
Mitigating the Inhibition of Human Bile Salt Export Pump by Drugs: Opportunities Provided by Physicochemical Property Modulation, In Silico Modeling, and Structural Modification
Daniel J. Warner, Hongming Chen, Louis-David Cantin, J. Gerry Kenna, Simone Stahl, Clare L. Walker and Tobias Noeske
Drug Metabolism and Disposition December 2012, 40 (12) 2332-2341; DOI: https://doi.org/10.1124/dmd.112.047068
Daniel J. Warner
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
Hongming Chen
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
Louis-David Cantin
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
J. Gerry Kenna
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
Simone Stahl
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
Clare L. Walker
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
Tobias Noeske
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, Montreal, Quebec, Canada (D.J.W., L.-D.C.); Computational Sciences, Discovery Sciences (H.C.), and Global Safety Assessment (T.N.), AstraZeneca R&D Mölndal, Mölndal, Sweden; and Molecular Toxicology, Global Safety Assessment, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom (J.G.K., S.S., C.L.W.)
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Research ArticleArticle
INHIBITION OF HUMAN BILE SALT EXPORT PUMP BY DRUGS
Daniel J. Warner, Hongming Chen, Louis-David Cantin, J. Gerry Kenna, Simone Stahl, Clare L. Walker and Tobias Noeske
Drug Metabolism and Disposition December 1, 2012, 40 (12) 2332-2341; DOI: https://doi.org/10.1124/dmd.112.047068
Research ArticleArticle
INHIBITION OF HUMAN BILE SALT EXPORT PUMP BY DRUGS
Daniel J. Warner, Hongming Chen, Louis-David Cantin, J. Gerry Kenna, Simone Stahl, Clare L. Walker and Tobias Noeske
Drug Metabolism and Disposition December 1, 2012, 40 (12) 2332-2341; DOI: https://doi.org/10.1124/dmd.112.047068
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