Research ArticleSymposium Report
Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
Hollie I. Swanson, Taira Wada, Wen Xie, Barbara Renga, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci, Bo Kong, Ann M. Thomas, Grace L. Guo, Ramesh Narayanan, Muralimohan Yepuru, James T. Dalton and John Y. L. Chiang
Drug Metabolism and Disposition January 2013, 41 (1) 1-11; DOI: https://doi.org/10.1124/dmd.112.048694
Hollie I. Swanson
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Taira Wada
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Wen Xie
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Barbara Renga
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Angela Zampella
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Eleonora Distrutti
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Stefano Fiorucci
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Bo Kong
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Ann M. Thomas
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Grace L. Guo
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Ramesh Narayanan
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
Muralimohan Yepuru
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
James T. Dalton
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
John Y. L. Chiang
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky (H.I.S.); Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W., W.X.); Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy (B.R., S.F.); Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II” Via D. Montesano Napoli-Italy (A.Z.) Azienda Ospedaliera di Perugia, Perugia, Italy (E.D.); Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (B.K., G.L.G); Translational Clinical Research Program, M.D. Anderson Cancer Center, Houston, Texas (A.M.T.); Preclinical Research and Development, GTx Inc., Memphis, Tennessee (R.N., M.Y., J.T.D.); and Department of Biochemistry and Molecular Pathology, Northeast Ohio Medical University, Rootstown, Ohio (J.Y.L.C.)
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In this issue
Research ArticleSymposium Report
Nuclear Receptors, Lipid, Glucose, and Drug Metabolism
Hollie I. Swanson, Taira Wada, Wen Xie, Barbara Renga, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci, Bo Kong, Ann M. Thomas, Grace L. Guo, Ramesh Narayanan, Muralimohan Yepuru, James T. Dalton and John Y. L. Chiang
Drug Metabolism and Disposition January 1, 2013, 41 (1) 1-11; DOI: https://doi.org/10.1124/dmd.112.048694
Research ArticleSymposium Report
Nuclear Receptors, Lipid, Glucose, and Drug Metabolism
Hollie I. Swanson, Taira Wada, Wen Xie, Barbara Renga, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci, Bo Kong, Ann M. Thomas, Grace L. Guo, Ramesh Narayanan, Muralimohan Yepuru, James T. Dalton and John Y. L. Chiang
Drug Metabolism and Disposition January 1, 2013, 41 (1) 1-11; DOI: https://doi.org/10.1124/dmd.112.048694
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- Article
- Abstract
- Introduction
- Endobiotic Functions of Xenobiotic Receptors and Xenobiotic Enzymes in Energy Metabolism
- Bile Acid–Activated Receptors in Regulating Lipid and Glucose Metabolism
- Tissue-Specific Functions of the FXR in the Liver and Intestine
- ER-β Selective Ligands as Novel Therapeutics for Obesity and Metabolic Diseases
- Summary and Future Directions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
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