Research ArticleSymposium Report
NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology
David S. Riddick, Xinxin Ding, C. Roland Wolf, Todd D. Porter, Amit V. Pandey, Qing-Yu Zhang, Jun Gu, Robert D. Finn, Sebastien Ronseaux, Lesley A. McLaughlin, Colin J. Henderson, Ling Zou and Christa E. Flück
Drug Metabolism and Disposition January 2013, 41 (1) 12-23; DOI: https://doi.org/10.1124/dmd.112.048991
David S. Riddick
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Xinxin Ding
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
C. Roland Wolf
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Todd D. Porter
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Amit V. Pandey
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Qing-Yu Zhang
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Jun Gu
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Robert D. Finn
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Sebastien Ronseaux
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Lesley A. McLaughlin
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Colin J. Henderson
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Ling Zou
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
Christa E. Flück
Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)
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In this issue
Research ArticleSymposium Report
Biological Roles of NADPH–Cytochrome P450 Oxidoreductase
David S. Riddick, Xinxin Ding, C. Roland Wolf, Todd D. Porter, Amit V. Pandey, Qing-Yu Zhang, Jun Gu, Robert D. Finn, Sebastien Ronseaux, Lesley A. McLaughlin, Colin J. Henderson, Ling Zou and Christa E. Flück
Drug Metabolism and Disposition January 1, 2013, 41 (1) 12-23; DOI: https://doi.org/10.1124/dmd.112.048991
Research ArticleSymposium Report
Biological Roles of NADPH–Cytochrome P450 Oxidoreductase
David S. Riddick, Xinxin Ding, C. Roland Wolf, Todd D. Porter, Amit V. Pandey, Qing-Yu Zhang, Jun Gu, Robert D. Finn, Sebastien Ronseaux, Lesley A. McLaughlin, Colin J. Henderson, Ling Zou and Christa E. Flück
Drug Metabolism and Disposition January 1, 2013, 41 (1) 12-23; DOI: https://doi.org/10.1124/dmd.112.048991
Jump to section
- Article
- Abstract
- Introduction
- Engineered Mouse Models Harboring Null or Hypomorphic Alleles for NADPH–Cytochrome P450 Oxidoreductase
- NADPH–Cytochrome P450 Oxidoreductase and Cytochrome b5 in Physiology, Drug Metabolism, and Cancer
- Replication of the Hepatic Lipidosis Seen in Hepatic Por-Null Mice in a Hepatoma Cell–Culture Model: A Role for Farnesoid X Receptor?
- Clinical, Structural, and Functional Implications of NADPH–Cytochrome P450 Oxidoreductase Deficiency
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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