Research ArticleArticle
Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response
Anne M. Filppula, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman
Drug Metabolism and Disposition January 2013, 41 (1) 50-59; DOI: https://doi.org/10.1124/dmd.112.048017
Anne M. Filppula
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland (A.M.F., M.N., J.L., P.J.N., J.T.B.) and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland (P.J.N., J.T.B.)
Mikko Neuvonen
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland (A.M.F., M.N., J.L., P.J.N., J.T.B.) and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland (P.J.N., J.T.B.)
Jouko Laitila
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland (A.M.F., M.N., J.L., P.J.N., J.T.B.) and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland (P.J.N., J.T.B.)
Pertti J. Neuvonen
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland (A.M.F., M.N., J.L., P.J.N., J.T.B.) and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland (P.J.N., J.T.B.)
Janne T. Backman
Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland (A.M.F., M.N., J.L., P.J.N., J.T.B.) and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland (P.J.N., J.T.B.)
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Important Role for CYP2C8 in Imatinib Metabolism
Anne M. Filppula, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman
Drug Metabolism and Disposition January 1, 2013, 41 (1) 50-59; DOI: https://doi.org/10.1124/dmd.112.048017
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