Research ArticleArticle
Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller and Lysiane Richert
Drug Metabolism and Disposition October 2013, 41 (10) 1835-1842; DOI: https://doi.org/10.1124/dmd.113.052415
Céline Parmentier
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Germaine L. Truisi
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Konrad Moenks
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Sven Stanzel
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Arno Lukas
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Annette Kopp-Schneider
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Eliane Alexandre
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Philip G. Hewitt
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Stefan O. Mueller
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
Lysiane Richert
KaLy-Cell, Plobsheim, France (C.P., E.A., L.R.); Non-Clinical Safety, Merck Serono, Merck KGaA, Darmstadt, Germany (G.L.T., P.G.H., S.O.M.); Emergentec Biodevelopment GmbH, Vienna, Austria (K.M., A.L.); Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany (S.S., A.K.-S.); Institut für Angewandte Biowissenschaften, Karlsruhe Institute of Technology, Karlsruhe, Germany (G.L.T., S.O.M.); and Laboratoire de Toxicologie Cellulaire, EA4267 Université de Franche-Comté, Besançon, France (L.R.)
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Research ArticleArticle
Chlorpromazine Toxicity on Human Hepatocyte Sandwich Cultures
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller and Lysiane Richert
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1835-1842; DOI: https://doi.org/10.1124/dmd.113.052415
Research ArticleArticle
Chlorpromazine Toxicity on Human Hepatocyte Sandwich Cultures
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller and Lysiane Richert
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1835-1842; DOI: https://doi.org/10.1124/dmd.113.052415
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