Index by author
December 01, 2013; Volume 41,Issue 12
A
Adams, Jerry L.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Adreani, Christine
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Alicke, Bruno
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Atkinson, Karen
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
B
Babu, Katipudi N.
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
Bartolomé, José M.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Bateman, Thomas J.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Bershas, David A.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Blackman, Samuel C.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Blobaum, Anna L.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Bloomer, Jackie C.
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Bonifácio, Maria João
- You have accessN-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase InhibitorAna I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-SilvaDrug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
Bouchene, Salim
- You have accessUtility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical DevelopmentFredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie PetersDrug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
Braun, Matthew
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Bridges, Thomas M.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Budha, Nageshwar
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Byers, Frank W.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
C
Callegari, Ernesto
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
Carson, Stanley W.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Chan, Tom S.
- You have accessMeeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPacTom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald TweedieDrug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
Chang, Cheng
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Christine, Amy
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Cole, Susan P.C.
- You have accessTwo Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1Gwenaëlle Conseil and Susan P.C. ColeDrug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213
Collin, Pierre
- You have accessModulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative SplicingVincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal GuillemetteDrug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
Conn, P. Jeffrey
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Conseil, Gwenaëlle
- You have accessTwo Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1Gwenaëlle Conseil and Susan P.C. ColeDrug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213
Cui, Julia Y.
- You have accessRNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in MiceLai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo ZhongDrug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
Cunningham, Paul K.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
D
Dai, Jing
- You have accessMetabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of HumansLin Xu, Caroline Woodward, Jing Dai and Chandra PrakashDrug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023
Daniels, J. Scott
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Darbonne, Walter C.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
de Morais, Sonia M.
- You have accessIn Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System ClassRyota Kikuchi, Sonia M. de Morais and J. Cory KalvassDrug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
Desta, Zeruesenay
- You have accessCYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic ModelingCong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay DestaDrug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
Di, Li
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Dolgos, Hugues
- You have accessUtility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical DevelopmentFredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie PetersDrug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
E
Easterling, Thomas R.
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Eng, Heather
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Erickson, Rebecca
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Evangelista, Eric A.
- You have accessActivity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary CardiomyocytesEric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. TotahDrug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
F
Fairbrother, Wayne J.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Fallon, John K.
- You have accessTargeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction MonitoringJohn K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. SmithDrug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
Feng, Bo
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
Fernandes-Lopes, Carlos
- You have accessN-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase InhibitorAna I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-SilvaDrug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
Flygare, John A.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Fujii, Tomoyuki
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Funk, Carrie
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
G
Generaux, Grant T.
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Goosen, Theunis C.
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
- You have accessTargeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction MonitoringJohn K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. SmithDrug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
Gorycki, Peter D.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Gould, Stephen E.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Guillemette, Chantal
- You have accessModulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative SplicingVincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal GuillemetteDrug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
Gunewardena, Sumedha S.
- You have accessRNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in MiceLai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo ZhongDrug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
Guo, Yingying
- You have accessCYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic ModelingCong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay DestaDrug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
H
Hall, Stephen D.
- You have accessCYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic ModelingCong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay DestaDrug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
Halladay, Jason S.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Hebert, Mary F.
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Hilgendorf, Constanze
- You have accessUtility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical DevelopmentFredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie PetersDrug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
Hong, Xuening
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Hop, Cornelis E. C. A.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Hori, Satoko
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Houston, J. Brian
- You have accessPrediction of Human Pharmacokinetics in 2013 and BeyondJ. Brian HoustonDrug Metabolism and Disposition December 2013, 41 (12) 1973-1974; DOI: https://doi.org/10.1124/dmd.113.055376
I
Infante, Jeffery R.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Isoherranen, Nina
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
J
Jeong, Hyunyoung
- You have accessCharacterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin TherapyNan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung JeongDrug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
Johnson, Chris V.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Jones, Carrie K.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Jones, J. P.
- You have accessActivity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary CardiomyocytesEric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. TotahDrug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
Jurusik, Kristen E.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
K
Kadel, Edward E.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Kalgutkar, Amit S.
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Kalvass, J. Cory
- You have accessIn Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System ClassRyota Kikuchi, Sonia M. de Morais and J. Cory KalvassDrug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
Karlsson, Fredrik H.
- You have accessUtility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical DevelopmentFredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie PetersDrug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
Kaspera, Rüdiger
- You have accessActivity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary CardiomyocytesEric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. TotahDrug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
Kelly, Edward J.
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Kharasch, Evan D.
- You have accessCytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-LopinavirEvan D. Kharasch and Kristi StubbertDrug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991
Khetani, Salman R.
- You have accessMeeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPacTom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald TweedieDrug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
Kikuchi, Ryota
- You have accessIn Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System ClassRyota Kikuchi, Sonia M. de Morais and J. Cory KalvassDrug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
Klaassen, Curtis D.
- You have accessRNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in MiceLai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo ZhongDrug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
Knecht, Dana M.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Kumar, Sanjeev
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Kunze, Kent L.
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
- You have accessCharacterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin TherapyNan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung JeongDrug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
L
La, Hank
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Lai, Yurong
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
Lavreysen, Hilde
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Lee, Nora
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Leung, Louis
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
Li, Hua
- You have accessAssessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte ModelXiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua LiDrug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
Li, Lang
- You have accessCYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic ModelingCong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay DestaDrug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
Limberakis, Chris
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Lin, Jian
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Lindsley, Craig W.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Loureiro, Ana I.
- You have accessN-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase InhibitorAna I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-SilvaDrug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
Lu, Chuang
- You have accessAssessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte ModelXiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua LiDrug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
Lu, Hong
- You have accessRNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in MiceLai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo ZhongDrug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
Lutz, Justin D.
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
M
MacDonald, Gregor J.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Mackie, Claire
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Mamaril-Fishman, Donna B.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Mamounas, Michael
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Margaillan, Guillaume
- You have accessModulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative SplicingVincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal GuillemetteDrug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
Matsuoka, Sayo
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Mattmann, Margrith E.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
McDonald, Thomas S.
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Ménard, Vincent
- You have accessModulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative SplicingVincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal GuillemetteDrug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
Mokadam, Nahush A.
- You have accessActivity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary CardiomyocytesEric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. TotahDrug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
Moore, Amanda
- You have accessMeeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPacTom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald TweedieDrug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
Morrison, Royce A.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Morrison, Ryan D.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
N
Nagai, Marie
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Nebot, Noelia
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Nelson, Wendel L.
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
Neubert, Hendrik
- You have accessTargeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction MonitoringJohn K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. SmithDrug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
Niswender, Colleen M.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Nunes, Christian N.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
O
Obach, R. Scott
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Ohtani, Hisakazu
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Orozco, Christine C.
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Ouellet, Daniele
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
P
Patel, Aarti H.
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Patel, Sheena
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Peng, Lai
- You have accessRNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in MiceLai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo ZhongDrug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
Peters, Sheila Annie
- You have accessUtility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical DevelopmentFredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie PetersDrug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
Plowchalk, David R.
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
Portera, Chia
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Prakash, Chandra
- You have accessMetabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of HumansLin Xu, Caroline Woodward, Jing Dai and Chandra PrakashDrug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023
Prasad, Bhagwat
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Q
Quinney, Sara K.
- You have accessCYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic ModelingCong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay DestaDrug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
R
Reddy, Vijay Bhasker G.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Richards-Peterson, Lauren E.
- You have accessMetabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic OxidationDavid A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-PetersonDrug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Rodrigues, A. David
- You have accessAssessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine ClearanceHong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David RodriguesDrug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
S
Satoh, Hiroki
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Sawada, Yasufumi
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Seguin, Ryan P.
- You have accessCharacterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin TherapyNan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung JeongDrug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
Shardlow, Carole E.
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Sharma, Raman
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Shen, Guo-Lin
- You have accessAssessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte ModelXiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua LiDrug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
Shen, Hong
- You have accessAssessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine ClearanceHong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David RodriguesDrug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
Shen, Xiaolan
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Smith, Philip C.
- You have accessTargeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction MonitoringJohn K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. SmithDrug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
Soares-da-Silva, Patrício
- You have accessN-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase InhibitorAna I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-SilvaDrug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
Staskiewicz, Steve J.
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Stauffer, Shaun R.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Steckler, Thomas
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Stevens, Benjamin D.
- You have accessIn Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human HepatocytesRaman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. KalgutkarDrug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
Steyn, Stefanus J.
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
Stubbert, Kristi
- You have accessCytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-LopinavirEvan D. Kharasch and Kristi StubbertDrug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991
T
Tai, Guoying
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Taketani, Yuji
- You have accessCharacterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered DosingMarie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi SawadaDrug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
Tan, Beijing
- You have accessIn Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay MethodLi Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
Tan, Yan
- You have accessAssessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte ModelXiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua LiDrug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
Tolcher, Anthony W.
- You have accessLearning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins AntagonistHarvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. FairbrotherDrug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
Totah, Rheem A.
- You have accessActivity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary CardiomyocytesEric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. TotahDrug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
Tran, Thuy
- You have accessImpact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug DevelopmentCarole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. BloomerDrug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
Trinh, Tu
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Tse, Susanna
- You have accessDrug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and DevelopmentErnesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna TseDrug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
Turlington, Mark L.
- You have accessHeterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug InteractionsAnna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott DanielsDrug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
Tweedie, Donald
- You have accessMeeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPacTom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald TweedieDrug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
U
Unadkat, Jashvant D.
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
V
VandenBrink, Brooke M.
- You have accessStereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor SystemsJustin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina IsoherranenDrug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
Varma, Manthena V.
- You have accessA Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and DevelopmentLi Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott ObachDrug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
W
Wang, Bo
- You have accessLymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and RatsYan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. ReddyDrug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
Wang, Joanne
- You have accessEffect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during PregnancyNora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne WangDrug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
Wong, Harvey
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Wright, Lyndon C.
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